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. Author manuscript; available in PMC: 2016 Feb 9.
Published in final edited form as: J Mammary Gland Biol Neoplasia. 2013 Nov 10;18(0):309–320. doi: 10.1007/s10911-013-9308-2

Figure 2. Leptin interacts with various important mediators of breast cancer.

Figure 2

Leptin produced by adipose tissue binds to leptin receptor expressing cells in the tumor microenvironment including breast cancer cells, breast cancer stem cells (BCSCs), endothelial cells, fibroblasts and immune cells. Leptin activates multiple oncogenic pathways and impacts various steps of tumor progression.