FIGURE 9. S100A9 is required in vivo for TLR3 activation.

Wild-type (WT) and S100A9 knockout (KO) mice [n=5 per group] were injected (via intraperitoneal or i.p. route) with polyIC (100 μg/mouse). Serum collected from the mice at 3h post-polyIC treatment was analyzed for interferon-β or IFN-β (A) and TNF-α or TNF (B) by ELISA. The values represent the mean ± standard deviation. *p <0.05 using Student’s t test.