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. 2015 Apr;87(4):561–571. doi: 10.1124/mol.114.096909

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Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 4. — Tachyphylaxis in N-terminal chimeras. (A) Representative current trace for ASIC2a elicited by five stimulations with pH 4 (tachyphylaxis protocol). (B) Representative current elicited by tachyphylaxis protocol in AB5-N. (C) Representative current elicited by tachyphylaxis protocol in ASIC2a-ASIC2b heteromers. (D) Graph comparing tachyphylaxis in ASIC2a, AB6, AB5-N, and ASIC2a + ASIC2b heteromers, currents normalized to the first current. AB5-N currents, but none of the others, were significantly different from ASIC2a. ****P < 0.0001.