Table III. Top Significant SNP Associations in EAs and AAs (in Bold) and the Corresponding Results in the Other Ethnic Population.
| Trait | SNP | Gene | A1/A2 | EA | AA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| AFA1 | N | Beta/SE, % | P value | AFA1 | N | Beta/SE, % | P value | ||||
| FVIII | rs698078 | KNG1 | A/G | 0.59 | 15,921 | 1.99/0.38 | 4.26 × 10−07 | 0.49 | 5,020 | 2.08/0.88 | 3.38 × 10−3 |
| rs710446 | KNG1 | T/C | 0.59 | 15,915 | 1.97/0.39 | 5.10 × 10−07 | 0.49 | 5,005 | 1.99/0.88 | 3.88 × 10−3 | |
| rs529565 | ABO | T/C | 0.65 | 15,921 | 17.03/0.37 | <1.0 × 10−199 | 0.62 | 5,020 | 17.40/0.88 | 1.81 × 10−92 | |
| rs8176693 | ABO | C/T | 0.93 | 15,921 | 14.90/0.70 | 5.65 × 10−105 | 0.90 | 5,020 | 37.24/1.65 | 2.51 × 10−114 | |
| rs2236568 | MAT1A | A/C | 0.45 | 15,917 | −0.15/0.38 | 0.75 | 0.76 | 5,004 | 5.28/1.06 | 1.69 × 10−6 | |
| rs1063856 | VWF | T/C | 0.64 | 15,913 | 2.68/0.40 | 5.84 × 10−12 | 0.42 | 5,005 | 4.61/0.89 | 3.92 × 10−06 | |
| rs7962217 | VWF | C/T | 0.94 | 15,914 | 4.84/0.83 | 6.30 × 10−9 | 0.98 | 4,372 | 6.96/3.40 | 2.98 × 10−2 | |
| rs216321 | VWF | C/T | 0.91 | 15,917 | −3.99/0.67 | 4.7 × 10−10 | 0.95 | 5,005 | −6.64/1.97 | 1.13 × 10−3 | |
| rs2229446 | VWF | C/T | 0.99 | 9,039 | 2.85/4.78 | 0.89 | 0.81 | 4,992 | −9.47/1.13 | 1.95 × 10−20 | |
| rs1800380 | VWF | C/T | 0.75 | 15,921 | 1.47/0.43 | 8.70 × 10−4 | 0.70 | 5,020 | 5.72/0.95 | 5.62 × 10−11 | |
| rs4764482 | VWF | T/C | 0.48 | 15,916 | −0.75/0.38 | 0.07 | 0.80 | 5,005 | −5.74/1.10 | 8.12 × 10−8 | |
| rs12557310 | TMLHE | C/T | 0.72 | 15,909 | −2.94/0.48 | 8.02 × 10−10 | 0.15 | 5,005 | −1.19/1.39 | 0.34 | |
| rs2096362 | F8 | G/A | 0.74 | 15,814 | −2.82/0.49 | 1.88 × 10−9 | 0.47 | 4,981 | 0.13/0.97 | 0.84 | |
| VWF | rs529565 | ABO | T/C | 0.66 | 12,863 | 22.18/0.50 | <1.0 × 10−199 | 0.62 | 3,460 | 23.90/1.30 | 1.23 × 10−76 |
| rs8176693 | ABO | C/T | 0.93 | 12,863 | 20.50/0.96 | 1.16 × 10−101 | 0.90 | 3,460 | 48.62/2.37 | 1.66 × 10−89 | |
| rs1063856 | VWF | T/C | 0.64 | 12,855 | 4.83/0.54 | 1.06 × 10−19 | 0.41 | 3,446 | 8.69/1.32 | 1.72 × 10−10 | |
| rs216321 | VWF | C/T | 0.91 | 12,858 | −7.24/0.92 | 1.71 × 10−17 | 0.95 | 3,267 | −9.86/2.96 | 2.50 × 10−3 | |
| rs2229446 | VWF | C/T | 0.99 | 9,043 | −16.72/6.14 | 0.05 | 0.81 | 3,435 | −12.67/1.68 | 1.13 × 10−16 | |
| rs1063856 | VWF | C/T | 0.36 | 12,855 | −4.83/0.54 | 1.06 × 10−19 | 0.59 | 3,446 | −8.69/1.32 | 1.72 × 10−10 | |
A1 = allele 1 (major allele in the ethnic population in which the associations were the middle significant ones, i.e. in bold), A2 = allele 2 (minor allele in the ethnic population in which the associations were the middle significant ones), AFA1 = average allele frequency for A1 allele in the corresponding ethnic population, Beta = change in trait level per 1 allele increase in the A2 allele based on untransformed measurements, SE = standard error.