Fig. 6.
Dose boost planning algorithm for both hypoxic region targeting and hypoxic region avoidance. (A) EPROI of an FSa fibrosarcoma tumor implanted and grown on a mouse leg. The white outline shows the tumor outline from registered MRI. (B) Same EPROI with the spherical hypoxic boost region (lightened dash red outline) and spherical shell anti-boost region (darker ring/blue dot outline).