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. Author manuscript; available in PMC: 2016 Feb 9.
Published in final edited form as: Science. 2015 Dec 3;350(6265):aad2459. doi: 10.1126/science.aad2459

Fig. 6. Failure of metabolic gene reprogramming after perinatal Mfn2 AA expression.

Fig. 6

(A) Heat map of mitochondrial gene expression in P1, P21, and 5 week mouse hearts; functional annotation of Mfn2 AA gene clusters is to the right. (B) Postnatal reprogramming of mitochondrial genes by metabolic function. Bars are mean values from results in Fig 4B; log(2) gene expression at 5 weeks vs P1 for Ctrl (top), WT Mfn2 (middle) and Mfn2 AA (lower) hearts. Blue and red bars are significantly down and upregulated, respectively (1.25 fold, FDR <0.02); black bars are not significantly regulated. (C) Regulated expression of mitochondrial biogenesis and replication genes during the perinatal-adult transition.

* = FDR<0.02 vs littermate control mice (TO). # is p<0.0001 vs WT Mfn2 (2-way ANOVA).