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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Pediatr Nephrol. 2015 Sep 25;31(2):247–253. doi: 10.1007/s00467-015-3203-6

Figure 2. Missense variant D3743N in TNXB resulted in perturbation of 28th fibronectin III domain of the protein.

Figure 2

I-TASSER was used to model the structure of TNXB FnIII domain 28. The model was predicted to be reliable with a robust C-scores 0.15-0.19. Residue D3743 (in red) is predicted to reside in fibronectin domain 28. Structural modeling of the 28th fibronectin III domain containing the D3743N variant (highlighted in red) resulted in, perturbation of the secondary structure of the protein.