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. 2015 Nov 22;6(39):41402–41417. doi: 10.18632/oncotarget.6356

Figure 4. DREAM binding to Survivin (BIRC5), CDC25C, and PLK1 is increased upon DNA damage induction and depends on p21.

Figure 4

Protein binding to the Survivin, CDC25C, and PLK1 promoters in untreated or HCT116 cells treated by doxorubicin for 48 h: HCT116 A. wild-type, B. p53−/−, or C. p21−/− cells. Binding of protein was tested by chromatin immunoprecipitation followed by real-time PCR. Protein binding to the GAPDHS promoter served as a negative control. One representative experiment with three technical replicates (n = 3) is displayed. Significance was tested using the paired Student's t-test; n.s. not significant; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.