Table 1. Association of VE1 staining with clinicopathological features and survival time in Cohort 1 (German cohort, only colon cancers).
| Feature | Negative (n=224; 86.5%) | Positive (n=35; 13.5%) | P-value | |
|---|---|---|---|---|
| Patient age (years) | Mean (min, max) | 64.3 (25-91) | 69.4 (34-90) | 0.0175 |
| Gender | Male | 125 (55.8) | 14 (40.0) | 0.0812 |
| Female | 99 (44.2) | 21 (60.0) | ||
| Tumor location | Right-sided | 32 (14.3) | 8 (22.9) | 0.1919 |
| Left-sided | 192 (85.7) | 27 (77.1) | ||
| pT | pT1-2 | 8 (3.6) | 1 (2.9) | 0.8301 |
| pT3-4 | 216 (96.4) | 34 (97.1) | ||
| pN | pN0 | 133 (59.6) | 21 (60.0) | 0.9679 |
| pN1-2 | 90 (40.4) | 14 (40.0) | ||
| pM | pM0 | 193 (86.6) | 31 (88.6) | 0.742 |
| pM1 | 30 (13.5) | 4 (11.4) | ||
| Tumor Grade | G1-2 | 201 (89.7) | 32 (91.4) | 0.7561 |
| G3-4 | 23 (10.3) | 3 (8.6) | ||
| Post-operative therapy | None | 134 (63.5) | 23 (69.7) | 0.49 |
| Treated | 77 (36.5) | 10 (30.3) | ||
| MLH1 expression | Deficient | 10 (4.5) | 16 (45.7) | <0.0001 |
| Proficient | 214 (95.5) | 19 (54.3) | ||
| Survival | All patients (5-year %) | 66.8 (61-72) | 63.7 (45-78) | 0.669 |
| pM1 patients (median) | 24 (14-33) | 4.5 (0-12) | <0.0001 |