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. 2015 Nov 2;6(39):41479–41496. doi: 10.18632/oncotarget.6286

Figure 6. Chronic consumption of diets enriched in PA plus MA leads to lipodystrophy and progressive liver disease and effect of myriocin therapy.

Figure 6

Mice were fed diets enriched in PA, MA or PA plus MA (PM) for 6 months with or without myriocin treatment in the last 4 months (PM+Myr). Effect on body weigh, liver/body weight, spleen weight and adipose tissue weight were recorded at the end of the study A. Serum transaminases levels were determined and liver processed for H&E analyses B. at the end of 6 months. Liver sections were staining for Sirius red to determine collagen deposition and expression of Col1α1 was determined by RT-PCR C. Inflammatory cytokine expression IL-1β, IL-6 and TNFα was examined in liver samples from mice fed PA, MA or PA plus MA (PM). Liver sections from mice were processed for oil-red staining E. Results are the mean±SEM of N = 8-10 individual mice. *p < 0.05 vs. control and PA-treated PMH.