Skip to main content
. 2015 Nov 2;6(39):41479–41496. doi: 10.18632/oncotarget.6286

Figure 7. Feeding diets enriched in PA with or without MA increased hepatic ceramide and cholesterol levels and induce ER stress.

Figure 7

Mice were fed diet enriched in PA with or without MA for 6 months as in Figure 6 and liver samples were processed for hepatic lipid content, ceramide, cholesterol, TG and FFA A. In some cases, mice were treated with myriocin (Myr) in vivo (i.p. 25mg/kg daily) for the last 4 months of feeding. Expression of hepatic CerS mRNA from mice fed PA, MA or PA plus MA (PM) B. Gene expression of enzymes involved in lipid metabolism and ceramide synthesis C. Western blot of ER stress markers from mice fed PA, MA or PA plus MA D. Results are the mean±SEM of N = 8-10 individual mice. *p < 0.05 vs. control and PA-treated PMH.