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Left panel: ZNF217-induced EMT involves the TGF-β pathway and several deregulated expression of EMT key members (E-cadherin, Snail, Slug, Twist and ZEB). Right panel: ZNF217 also induces deregulation in ErbB2-ErbB3, eEF1A2, Aurora-A and several adhesion molecules associated with the activation of complex subcircuits (e.g. FAK, PI3K/Akt) leading to EMT, invasion and metastases development.
