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. 2015 Oct 19;6(39):41736–41749. doi: 10.18632/oncotarget.6153

Figure 1. Caspase 3/7 activity in SKOV3 and PEO4 cells exposed to GSK2141795 as a single agent or in combination with cisplatin.

Figure 1

SKOV3 and PEO4 monolayers (A. and B., respectively) and SKOV3 spheroids C. were pre-treated with a range of concentrations of GSK2141795, 1 hour prior to treatment with cisplatin (cddp; 25 μM). Induction of caspase 3/7 activity was assessed at 24 hours following the initiation of the treatment for the monolayers A. and B. and at 72 hours for the spheroid C.. Data shown are the means ± SEM of 3-4 experiments performed in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001 (paired t-test).