Figure 5. Fluorizoline modulates the expression of BCL-2 family members by targeting PHBs in MEFs.

a. Phb2^fl/fl MEFs were untreated (white bars) or treated with 20 μM fluorizoline (black bars) for 24 h. b. Phb2^fl/fl MEFs were transduced with Cre recombinase for 72 h (Phb2^−/−) and then untreated or treated with 20 μM fluorizoline for 24 h. a., b. mRNA levels were analyzed by RT-MLPA. White bars correspond to untreated cells, and black bars to fluorizoline-treated cells. Data show the mean values ± SEM of three independent experiments relative to the mean of the control. *p < 0.05, **p < 0.01, ***p < 0.001 untreated versus treated cells.