Table 3. Pharmacokinetic parameters in mice after administration of free drug, single drug-loaded NPs, and Co-FANPs containing CDDP and/or PTX (mean ± SD, n = 6).
| Drug | Dose (mg/kg) | AUC (μg*h/mL) | CL (L/h/kg) | MRT (h) | t1/2(h) | Vd,ss (L/kg) | |
|---|---|---|---|---|---|---|---|
| Free-drug loaded | Free-CDDP | 5 | 10.09±1.06 | 0.69±0.03 | 6.76±1.15 | 4.91±0.28 | 2.08±0.07 |
| Free-PTX | 12 | 14.38±2.67 | 0.84±0.04 | 1.17±0.14 | 0.97±0.09 | 0.56±0.06 | |
| FA-NPs loaded | CDDP | 5 | 29.02±3.41 | 0.28±0.03 | 11.85±1.62 | 8.6±1.14 | 2.57±0.34 |
| PTX | 12 | 32.59±3.85 | 0.49±0.03 | 1.87±0.23 | 1.11±0.12 | 0.57±0.05 | |
| Co-FA-NPs | CDDP | 5 | 32.21±2.44 | 0.26±0.07 | 14.07±1.46 | 10.25±1.91 | 2.74±0.45 |
| PTX | 12 | 52.34±5.36 | 0.33±0.02 | 2.89±0.52 | 1.78±0.16 | 0.61±0.11 |