. 2015 Nov 3;6(39):42380–42393. doi: 10.18632/oncotarget.5675

Table 3. Statistical values of all metrics for differentiating between HGGs and LGGs, grade II and grade III, and grade III and grade IV gliomas.

Metrics	AUC	P Value	Cut-off value	Sensitivity	Specificity
HGGs-LGGs
MK	0.932	< 0.001^*	0.553	90.00%	88.20%
Ka	0.906	< 0.001^*	0.655	87.50%	85.30%
Kr	0.921	< 0.001^*	0.443	87.50%	88.20%
MD(10⁻³ mm²/sec)	0.833	< 0.001^*	1.573	72.50%	85.30%
FA	0.618	0.081	0.324	80.00%	44.10%
ADC(10⁻³ mm²/sec)	0.815	< 0.001^*	1.627	77.50%	76.50%
Grade II–III
MK	0.874	< 0.001^*	0.553	84.20%	87.10%
Ka	0.827	< 0.001^*	0.655	78.90%	83.90%
Kr	0.864	< 0.001^*	0.436	84.20%	83.90%
MD(10⁻³ mm²/sec)	0.776	< 0.001^*	1.627	73.70%	80.60%
FA	0.640	0.079	0.287	94.70%	32.30%
ADC(10⁻³ mm²/sec)	0.716	0.004	1.575	63.20%	77.40%
Grade III–IV
MK	0.835	< 0.001^*	0.667	85.70%	84.20%
Ka	0.840	< 0.001^*	0.825	76.20%	89.50%
Kr	0.845	< 0.001^*	0.538	81.00%	84.20%
MD(10⁻³ mm²/sec)	0.729	0.013^*	1.409	66.70%	78.90%
FA	0.551	0.579	0.334	38.10%	78.90%
ADC(10⁻³ mm²/sec)	0.737	0.003^*	1.400	76.20%	68.40%

Note: The cut-off value indicates the optimal threshold in the current study/sample size. All metrics are dimensionless, except for MD and ADC.

P < 0.05.

AUC: area under the curve; HGGs: high-grade gliomas; LGGs: low-grade gliomas; MK: mean kurtosis; Ka: axial kurtosis; Kr: radial kurtosis; MD: mean diffusivity; FA: fractional anisotropy; ADC: apparent diffusion coefficient.