Table 2.

Selection probability and number of patients treated at each dose-schedule combination, with the target dose-schedule combinations in boldface.

Dose	Proposed design						Independent TR design
	Selection percentage			Number of patients			Selection percentage			Number of patients
	Schedule			Schedule			Schedule			Schedule
	1	2	3	1	2	3	1	2	3	1	2	3
	Scenario 1
1	0.3	0	0.9	2	2	2.2	0.5	0.4	2.9	2.2	2.3	3.1
2	4.6	1.5	19.2	2.8	2.2	5.2	5.2	1.2	11.8	3.4	2.4	6.1
3	48.3	4.3	5.3	8.2	2.9	4.4	39.4	5.1	11.6	5.3	2.8	3.3
4	3.2	8.7	0.5	2.8	3.1	1.7	9	11.9	1	2.8	6	1.3
	Scenario 2
1	5.5	3.2	3.9	2.7	2.4	2.6	5	2.9	5.1	5.9	3.3	5.9
2	15.1	48.9	14.2	5.6	9.1	5.6	15.3	34.2	20.2	5.3	6.3	5.1
3	1	5.9	1.5	2.3	3.9	2.5	2.4	11.5	3	2.1	3	2.1
4	0	0.2	0.1	0.9	1.3	1	0.1	0.2	0.1	0.4	1.1	0.5
	Scenario 3
1	40.2	6.5	0	6.8	3	2	25	9.9	0.3	6.1	7.1	2.2
2	19.3	6.9	16.4	6.6	5.1	4.7	20.8	16.4	10.7	4.1	4.6	6.2
3	0.5	0.6	8.6	1.9	2	4.8	0.6	0.2	15.7	1.5	1.7	3.8
4	0	0	0	0.7	0.6	1.6	0	0	0.2	0.4	0.3	1.6
	Scenario 4
1	0.2	0.9	2.9	2.1	2.2	2.5	0	0	0.2	2	2	2.1
2	0.3	0.9	5.1	2.1	2.2	2.8	0	0	0.5	2	2	2.2
3	0.6	1.2	11.8	2.2	2.4	4.2	0	0.2	9.1	2	2.1	3.1
4	1	10.7	63.6	2.5	4	10.8	6.8	20.2	63	7.3	7.5	6.6
	Scenario 5
1	0.1	0.1	0.1	2	2	2	0	0.1	0	2.1	2.2	2.2
2	0.3	1.1	1.9	2.1	2.3	2.6	0.2	1.5	3	2.1	2.6	3.3
3	3	16.6	44.1	2.6	4.5	8.1	2.6	10.4	25.5	2.7	4.8	4.9
4	17.1	7.9	6.8	4	3.8	3.7	35.9	11.3	9.5	6.7	4	3.4
	Scenario 6
1	0	0.4	2.9	2	2.2	3	0	1.1	4.6	2.1	2.9	3.5
2	1.4	45	1.4	2.4	9.1	2.4	3.4	33	1.1	3	6.5	1.1
3	39.1	5.6	0.2	8.4	5	0.9	33.6	10.7	0	5.5	3.2	0.2
4	3.6	0.1	0.1	2.8	1.6	0.3	11.5	0.8	0	3.3	1.2	0.1
	Scenario 7
1	2.1	6.1	21.1	2.3	3	4.6	1.6	5.9	17	3.2	6.2	6.4
2	31.5	11.7	9.8	6.4	5.2	4.7	22.1	15.8	13.3	5.4	4.4	3.6
3	8.9	3.2	2.4	5	2.9	2.3	13.3	3.2	3.1	3.4	2	1.5
4	1.8	0	0	1.7	1	0.8	3.9	0.5	0.1	1.7	0.5	0.4
	Scenario 8
1	0	0.8	0	2	2.1	2	0	0.5	0.1	2.1	2.9	2.1
2	1	30.8	1.1	2.3	6.3	2.3	1.4	20.7	1.8	2.9	6.2	2.9
3	30	7.6	22.6	6.3	4.7	5.4	22.8	12.1	21.9	5.5	3.4	5.4
4	2.2	0.2	3.7	2.5	1.6	2.5	9.5	0.3	8.9	3.3	1.3	3.4
	Scenario 9
1	0.4	0.9	0	2	2.1	2	0.2	0.4	0	2.2	2.2	2
2	13.5	4.7	0.1	4.3	2.9	2	15.2	6	0	6	3.6	2
3	8.9	58.8	0.6	5.3	9.4	2.1	11.8	44.4	0.3	3.9	5.4	2.1
4	0.8	2.8	6.1	2	2.8	2.8	1	3.6	17	1.8	2.5	7.3
	Scenario 10
1	1	8.2	2.3	2.2	3.2	2.3	1.1	12.3	1.5	5	7	2.7
2	15.9	6.3	33.7	5.5	4.5	6.3	15.5	16.7	24.1	5.2	4.2	4.8
3	6.8	1	17.9	3.8	2.1	5.7	6.6	1.2	15.7	2.5	1.6	3.9
4	1	0.4	4.6	1.3	0.8	2.1	0.9	0	4	0.8	0.3	2.4
	Scenario 11
1	6	0	1.2	3.5	2	2.2	4.3	0.1	6.1	3.9	2.1	3.7
2	2.2	2.2	42.3	2.9	2.5	9.2	1.1	5.9	36.7	1.5	3.5	6.5
3	0.3	40.9	1	1.3	8.8	3.1	0	31.8	6.1	0.4	5.2	2.7
4	0	2.1	0.1	1.7	1	0.8	3.9	0.5	0.1	1.7	0.5	0.4
	Scenario 12
1	0.1	2	1.9	2.2	2.4	2.5	0	0	0	2	2	2
2	1.2	1.9	2	2.2	2.3	2.5	0	0	0.1	2	2	2.1
3	1.1	4.8	5	2.2	2.9	3	0	0.3	1.4	2	2.1	2.3
4	4.4	17	56.6	3	4.8	9.9	5.6	20.7	71.8	7.1	7.5	7.5