Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Headache scores
[26] RCT	60 people (diagnosed with IHS criteria[17])	Percentage improvement in VAS score (scale 0–10); subjective assessment of combined headache frequency and intensity 65% with mirtazapine 58% with amitriptyline	Reported as not significant P value not reported Both treatments significantly reduced headache frequency and severity from baseline		Not significant