A 50-year-old woman presented with dysarthria, left hemiplegia, neglect, and right gaze deviation (NIHSS=19). Intravenous tPA was administered 93 minutes after onset. A, Pretreatment DWI obtained 70 minutes after symptom onset; B, pretreatment mean transit time; C, 90-day follow-up FLAIR. The initial DWI lesion volume was 72 cm3 and chronic lesion volume 12 cm3 (83% reduction). Three months later, she had mild facial weakness and sensory loss; her mRS=1.