Table 2.

Association of Clinical and Imaging Variables and Outcome

Variable	Excellent Outcome			Independent Outcome
	mRS 0–1 (N=32)	mRS 2–6 (N=21)	P Value	mRS 0–2 (N=37)	mRS 3–6 (N = 16)	P Value
Age, mean±SEM	65.1±2.8	75.1±2.3	0.008	65.5±2.5	77.3±2.4	0.007
NIHSS			0.002			<0.001
0–4	15	4		17	2
5–11	13	5		16	2
>11	4	12		4	12
Pre-tPA glucose, mg/dL; mean±SEM	119.2±4.8	134.6±15.9	0.841	119.1±4.3	139.7±20.7	0.985
Onset to treatment, minutes; mean±SEM	139.6±5.6	140.4±6.5	0.93	140.5±5.1	138.6±7.6	0.84
DWI volume, cm3; mean±SEM	11.4±3.4	30.6±9.8	0.033	11.9±3.4	32.3±12.1	0.037
FLAIR volume, cm3; mean±SEM	6.1±2.1	68.2±21.0	<0.001	8.6±2.6	81.7±26.6	<0.001
Volume change, cm3; mean±SEM	−5.3±3.4	37.6±17.5	0.001	−3.3±3.2	46.4±22.6	0.003
Is mismatch present?*			1.0			1.0
Yes	25	12		29	8
No	6	2		6	2
Is mismatch present?†			0.179			0.178
Yes	24	21		27	18
No	5	10		6	9
Volume decrease ≥30%			0.004			0.013
Yes	17	3		18	2
No	15	18		19	14
Volume increase ≥30%			0.102			0.127
Yes	14	14		17	11
No	18	7		20	5
Volume decrease ≥5 cm3			0.160			0.299
Yes	10	3		11	2
No	22	18		26	14
Volume increase ≥5 cm3			0.002			0.002
Yes	5	12		7	10
No	27	9		30	6

^*N=45; mismatch is defined as volume of mean transit time delay 20% larger than volume of DWI abnormality.

^†Includes data from 15 patients who died before follow-up MRI was done but who had baseline mean transit time images.