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. 2015 Oct 22;6(38):40719–40733. doi: 10.18632/oncotarget.5825

Figure 5. Inhibition of ATM and NF-κB activation abrogates the effect of IL-6 on MMP-3/MMP-13 up-regulation.

Figure 5

A panel of lung cancer cells was pretreated with inhibitors of ATM (CGK733, 20 μM), p65 (BAY11–7082, 20 μM) a. or siRNA transfection b–c. prior to (5 ng/ml) IL-6 (a-b) or PBS (c) treatment. The expressions of MMP-3 and MMP-13 were determined by western blot (a) and RT-qPCR (b-c). The relative band intensity of MMP-3/MMP-13 in western blot was quantified using IMAGE J software and indicated under each lane. The data are presented as the mean ± SEM, n = 3. **p < 0.01, ***p < 0.001, One-way ANOVA with post Newman-Keuls test. One representative from three experiments is shown. CGK733 and BAY11–7082 were shown as CGK and BAY, respectively, for limited space in the figure.