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. 2015 Oct 19;6(38):40850–40865. doi: 10.18632/oncotarget.5813

Figure 8. Effect of cetuximab on the cell membrane fluidity in EGFR negative K562/adr cells.

Figure 8

The protein level of EGFR was measured by western blot analysis as described in “Materials and Methods”. Western blot analysis confirmed that the EGFR was negative in K562 and K562/adr cells and positive in KBv200 cells A. A fluidity of tumor cell membrane assay was performed as described in “Materials and Methods”. Cetuximab did not alter the fluorescence polarization and fluidity of the membrane in K562/adr cells B. The MTT assay was performed as described in “Materials and Methods”. Cetuximab did not enhanced the cytotoxicity of DOX in ABCB1-overexpressing K562/adr cells but verapamil could do in K562/adr cells C.