Figure 1. The main idea behind our approach.

A. Three gene lists identified in drug-induced resistant cell models. B. Evaluation of clinical relevance of candidate drug resistance gene derived from drug-induced resistant cell models and post-chemotherapy cancer specimens. Abbreviations: BD genes: basally deregulated genes detected between parental cell line and resistant cell line; IP genes: genes detected between parental and drug-treated parental cells; ID genes: genes detected between drug-treat parental cell line and drug-treat resistant cell line; clinically relevant drug resistance genes (CRGs): DEGs between the pre-chemotherapy clinical specimens of responders and non–responders; ID_clinical genes: DEGs between the post-chemotherapy clinical specimens of responders and non–responders.