Table 3. The consistency scores of CRG5-FU/L-OHP and the top-ranked 3000 BD genes or ID genes.
| Dataset | Drug | Cell line | Gene set | Method | Overlapped DEGa | Consistent DEG(%)b | Binominal P-value |
|---|---|---|---|---|---|---|---|
| E-MEXP-390 | 5-FU/L-OHP | HCT116 | BDtwo | FC | 40 | 45.00 | >1.00E-01 |
| AD | 45 | 64.44 | 3.62E-02 | ||||
| IDtwo-6 | FC | 11 | 54.55 | >1.00E-01 | |||
| AD | 24 | 54.17 | >1.00E-01 | ||||
| IDtwo-12 | FC | 18 | 55.56 | >1.00E-01 | |||
| AD | 33 | 57.58 | >1.00E-01 | ||||
| IDtwo-24 | FC | 10 | 70.00 | 1.72E-01 | |||
| AD | 38 | 84.21 | 1.22E-05 | ||||
| E-MEXP-390 | 5-FU | HCT116 | BD | FC | 74 | 51.35 | >1.00E-01 |
| AD | 70 | 68.57 | 1.27E-03 | ||||
| ID6 | FC | 79 | 55.70 | >1.00E-01 | |||
| AD | 71 | 52.11 | >1.00E-01 | ||||
| ID12 | FC | 85 | 77.65 | 1.52E-07 | |||
| AD | 89 | 74.16 | 2.85E-06 | ||||
| ID24 | FC | 79 | 55.70 | >1.00E-01 | |||
| AD | 79 | 72.15 | 5.13E-05 | ||||
| E-MEXP-390 | L-OHP | HCT116 | BD | FC | 85 | 43.53 | >1.00E-01 |
| AD | 78 | 57.69 | >1.00E-01 | ||||
| ID6 | FC | 60 | 50.00 | >1.00E-01 | |||
| AD | 70 | 51.43 | >1.00E-01 | ||||
| ID12 | FC | 92 | 28.26 | >1.00E-01 | |||
| AD | 82 | 35.37 | >1.00E-01 | ||||
| ID24 | FC | 71 | 74.65 | 1.94E-05 | |||
| AD | 71 | 83.10 | 6.74E-09 | ||||
| GSE10405 | L-OHP | DLD1 | BD | FC | 20 | 70.00 | >1.00E-01 |
| AD | 21 | 57.14 | >1.00E-01 | ||||
| HT29 | FC | 26 | 42.31 | >1.00E-01 | |||
| AD | 16 | 43.75 | >1.00E-01 | ||||
| LS513 | FC | 18 | 55.56 | >1.00E-01 | |||
| AD | 21 | 52.38 | >1.00E-01 | ||||
| Lovo | FC | 23 | 43.48 | >1.00E-01 | |||
| AD | 15 | 53.33 | >1.00E-01 |
Abbreviations: ID: inducible difference genes;
a
The number of candidate drug resistance genes overlapped with CRG5-FU/L-OHP;
b
The consistency score of candidate drug resistance genes and CRG5-FU/L-OHP.