Table 1. Top up and down regulated genes in adenocarcinoma, AOM- and DSS-treated colon mucosae.
| Accession number | Gene name | Gene description | log2FC | log2 average expression | BH corrected p-value | Experimental group |
|---|---|---|---|---|---|---|
| 13240 | Defa6 | defensin, alpha, 6 | 6.78 | 9.44 | 5.95E-22 | adenocarcinoma |
| 18780 | Pla2g2a | phospholipase A2, group IIA (platelets, synovial fluid) | 6.68 | 10.19 | 3.28E-22 | adenocarcinoma |
| 100503970 | AY761185 | defensin related… | 6.61 | 9.37 | 2.36E-20 | adenocarcinoma |
| 18946 | Pnliprp1 | pancreatic lipase-related protein 1 | 6.40 | 9.94 | 3.28E-22 | adenocarcinoma |
| 13222 | Defa-rs2 | defensin, alpha, 3 | 6.04 | 9.41 | 2.60E-18 | adenocarcinoma |
| 13238 | Defa4 | defensin, alpha, 4 | 5.72 | 9.26 | 5.20E-17 | adenocarcinoma |
| 16673 | Krt36 | keratin 36 | 5.25 | 9.97 | 4.66E-19 | adenocarcinoma |
| 17384 | Mmp10 | matrix metallopeptidase 10 (stromelysin 2) | 5.22 | 9.59 | 5.87E-17 | adenocarcinoma |
| 94214 | Spock2 | sparc/osteonectin | 5.11 | 9.33 | 4.86E-20 | adenocarcinoma |
| 17386 | Mmp13 | matrix metallopeptidase 13 (collagenase 3) | 5.02 | 10.19 | 1.10E-16 | adenocarcinoma |
| 77583 | Notum | Notum pectinacetylesterase homolog (Drosophila) | 5.00 | 9.21 | 1.04E-16 | adenocarcinoma |
| 94179 | Krt23 | keratin 23 (histone deacetylase inducible) | 4.78 | 10.49 | 4.48E-17 | adenocarcinoma |
| 17082 | Il1rl1 | interleukin 1 receptor-like 1 | 4.75 | 9.35 | 1.07E-21 | adenocarcinoma |
| 13218 | Defa-rs1 | defensin, alpha, related sequence 1 | 4.72 | 9.12 | 1.92E-17 | adenocarcinoma |
| 230810 | Slc30a2 | solute carrier family 30 (zinc transporter), member 2 | 4.69 | 9.02 | 3.28E-22 | adenocarcinoma |
| 23966 | Odz4 | teneurin transmembrane protein 4 | 4.67 | 9.30 | 4.55E-20 | adenocarcinoma |
| 213948 | Atg9b | autophagy related 9B | 4.67 | 9.14 | 8.28E-20 | adenocarcinoma |
| 18791 | Plat | plasminogen activator, tissue | 4.65 | 9.86 | 4.51E-17 | adenocarcinoma |
| 18947 | Pnliprp2 | pancreatic lipase-related protein | 4.51 | 9.19 | 1.89E-17 | adenocarcinoma |
| 68713 | Ifitm1 | interferon induced transmembrane protein 1 | 4.48 | 11.11 | 3.43E-16 | adenocarcinoma |
| 99709 | AI747448 | autophagy related 9B | 4.35 | 9.65 | 1.96E-13 | adenocarcinoma |
| 56753 | Tacstd2 | tumor-associated calcium signal transducer 2 | 4.35 | 9.15 | 5.20E-17 | adenocarcinoma |
| 20210 | Saa3 | serum amyloid A 3 | 4.34 | 9.17 | 3.51E-18 | adenocarcinoma |
| 14733 | Gpc1 | glypican 1 | 4.31 | 11.01 | 1.03E-15 | adenocarcinoma |
| 12006 | Axin2 | axin2 | 4.16 | 10.22 | 1.37E-15 | adenocarcinoma |
| 14038 | Wfdc18 | WAP four-disulfide core domain 18 | 4.16 | 9.48 | 1.82E-14 | adenocarcinoma |
| 13216 | Defa1 | defensin, alpha 1 | 4.08 | 8.92 | 1.13E-15 | adenocarcinoma |
| 11833 | Aqp8 | aquaporin 8 | −4.96 | 13.31 | 1.05E-14 | adenocarcinoma |
| 12351 | Car4 | carbonic anhydrase 4 | −4.70 | 12.54 | 2.68E-18 | adenocarcinoma |
| 192113 | Atp12a | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | −4.44 | 12.63 | 1.18E-12 | adenocarcinoma |
| 56857 | Slc37a2 | solute carrier family 37, member 2 | −4.43 | 10.94 | 1.82E-14 | adenocarcinoma |
| 11537 | Cfd | complement factor D | −4.20 | 11.50 | 5.17E-05 | adenocarcinoma |
| 20341 | Selenbp1 | selenium binding protein 1 | −4.12 | 13.61 | 2.56E-16 | adenocarcinoma |
| 13170 | Dbp | D site albumin promoter binding protein | −3.91 | 11.05 | 1.05E-08 | adenocarcinoma |
| 72082 | Cyp2c55 | cytochrome P450, family 2, subfamily c, polypeptide 55 | −3.90 | 12.58 | 6.66E-12 | adenocarcinoma |
| 380997 | Cyp2d12 | cytochrome P450, family 2, subfamily d, polypeptide 12 | −3.70 | 10.82 | 7.34E-17 | adenocarcinoma |
| 23919 | Insl5 | insulin-like 5 | −3.68 | 11.12 | 1.77E-15 | adenocarcinoma |
| 20500 | Slc13a2 | solute carrier family 13, member 2 | −3.68 | 12.17 | 7.29E-13 | adenocarcinoma |
| 72273 | 2210404O07Rik | small integral membrane protein | −3.66 | 12.49 | 1.92E-14 | adenocarcinoma |
| 216225 | Slc5a8 | solute carrier family 5 (iodide transporter), member 8 | −3.56 | 12.81 | 7.78E-13 | adenocarcinoma |
| 21818 | Tgm3 | transglutaminase 3, E polypeptide | −3.47 | 11.03 | 2.63E-13 | adenocarcinoma |
| 382097 | Gm1123 | predicted gene 1123 | −3.45 | 11.67 | 3.95E-13 | adenocarcinoma |
| 20342 | Selenbp2 | selenium binding protein 2 | −3.43 | 11.25 | 1.59E-14 | adenocarcinoma |
| 11522 | Adh1 | alcohol dehydrogenase 1 (class I) | −3.37 | 13.98 | 9.73E-12 | adenocarcinoma |
| 20363 | Sepp1 | selenoprotein P, plasma, 1 | −3.34 | 12.83 | 3.79E-14 | adenocarcinoma |
| 68416 | Sycn | syncollin | −3.34 | 14.97 | 9.25E-12 | adenocarcinoma |
| 64385 | Cyp4f14 | cytochrome P450, family 4, subfamily f, polypeptide 14 | −3.29 | 12.48 | 1.58E-12 | adenocarcinoma |
| 234669 | Ces2b | carboxyesterase 2B | −3.24 | 11.00 | 6.07E-15 | adenocarcinoma |
| 13105 | Cyp2d9 | cytochrome P450, family 2, subfamily d, polypeptide 9 | −3.22 | 11.05 | 2.32E-12 | adenocarcinoma |
| 20887 | Sult1a1 | sulfotransferase family 1A, phenol-preferring, member 1 | −3.19 | 12.30 | 1.78E-15 | adenocarcinoma |
| 13346 | Des | desmin | −3.16 | 11.60 | 1.53E-10 | adenocarcinoma |
| 13113 | Cyp3a13 | cytochrome P450, family 3, subfamily a, polypeptide 13 | −3.13 | 11.30 | 1.46E-14 | adenocarcinoma |
| 53315 | Sult1d1 | sulfotransferase family 1D, member 1 | −3.12 | 11.12 | 1.28E-14 | adenocarcinoma |
| 393082 | Mettl7a2 | methyltransferase like 7A2 | −3.11 | 9.63 | 4.52E-10 | adenocarcinoma |
| 13101 | Cyp2d10 | cytochrome P450, family 2, subfamily d, polypeptide 10 | −3.10 | 11.64 | 5.38E-14 | adenocarcinoma |
| 56643 | Slc15a1 | solute carrier family 15 (oligopeptide transporter), member 1 | −3.02 | 10.38 | 5.60E-17 | adenocarcinoma |
| 14734 | Gpc3 | glypican-3 | -1.15 | 8.94 | 1.14E-08 | adenocarcinoma |
| 93695 | Gpnmb | glycoprotein (transmembrane) nmb | 1.81 | 10.01 | 1.26E-05 | AOM |
| 12653 | Chgb | chromogranin B | 1.57 | 10.46 | 2.95E-06 | AOM |
| 15360 | Hmgcs2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | 1.49 | 12.65 | 3.87E-02 | AOM |
| 75646 | Rai14 | retinoic acid induced 14 | 1.37 | 7.32 | 2.45E-02 | AOM |
| 76459 | Car12 | carbonic anyhydrase 12 | 1.28 | 10.38 | 7.15E-04 | AOM |
| 21990 | Tph1 | tryptophan hydroxylase 1 | 1.12 | 8.88 | 2.82E-07 | AOM |
| 26914 | H2afy | H2A histone family, member Y | −2.61 | 8.71 | 3.08E-15 | AOM |
| 13170 | Dbp | D site albumin promoter binding protein | −2.56 | 11.05 | 5.15E-04 | AOM |
| 225742 | St8sia5 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 | −2.3 | 9.07 | 1.75E-07 | AOM |
| 108017 | Fxyd4 | FXYD domain-containing ion transport regulator 4 | −2.22 | 10.23 | 1.04E-05 | AOM |
| 393082 | Mettl7a2 | methyltransferase like 7A2 | −1.83 | 9.63 | 1.93E-04 | AOM |
| 192113 | Atp12a | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | −1.66 | 12.63 | 8.85E-04 | AOM |
| 229599 | Gm129 | circadian associated repressor of transcription | −1.65 | 8.93 | 7.08E-06 | AOM |
| 17748 | Mt1 | metallothionein 1 | −1.6 | 14.81 | 3.45E-06 | AOM |
| 380997 | Cyp2d12 | cytochrome P450, family 2, subfamily d, polypeptide 12 | −1.52 | 10.82 | 1.75E-07 | AOM |
| 66184 | Rps4y2 | ribosomal protein S4-like | −1.52 | 8.43 | 1.55E-09 | AOM |
| 17829 | Muc1 | mucin 1, transmembrane | −1.4 | 9.57 | 1.31E-04 | AOM |
| 67133 | Gp2 | glycoprotein 2 (zymogen granule membrane) | −1.27 | 10.00 | 3.27E-03 | AOM |
| 20208 | Saa1 | serum amyloid A 1 | −1.22 | 11.16 | 3.60E-03 | AOM |
| 12346 | Car1 | carbonic anhydrase 1 | −1.21 | 14.02 | 1.05E-02 | AOM |
| 56857 | Slc37a2 | solute carrier family 37, member 2 | −1.21 | 10.94 | 2.07E-03 | AOM |
| 13105 | Cyp2d9 | cytochrome P450, family 2, subfamily d, polypeptide 9 | −1.2 | 11.05 | 1.29E-03 | AOM |
| 67204 | Eif2s2 | eukaryotic translation initiation factor 2, subunit 2 (beta) | −1.19 | 11.80 | 7.47E-06 | AOM |
| 27409 | Abcg5 | ATP-binding cassette, sub-family G (WHITE), member 5 | −1.17 | 11.49 | 4.01E-03 | AOM |
| 13034 | Ctse | cathepsin E | −1.15 | 11.54 | 8.49E-04 | AOM |
| 53376 | Usp2 | ubiquitin specific peptidase 2 | −1.14 | 9.19 | 6.67E-05 | AOM |
| 207952 | Klhl25 | kelch-like 25 | −1.06 | 8.24 | 6.88E-07 | AOM |
| 208715 | Hmgcs1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | −1.03 | 14.25 | 6.52E-03 | AOM |
| 20692 | Sparc | secreted acidic cysteine rich glycoprotein | −1.01 | 10.58 | 7.42E-03 | AOM |
| 67080 | 1700019D03Rik | RIKEN cDNA 1700019D03 gene | −1 | 11.38 | 1.40E-03 | AOM |
| 66660 | Sltm | SAFB-like, transcription modulator | 2.36 | 8.82 | 3.75E-02 | DSS |
| 12653 | Chgb | chromogranin B | 1.6 | 10.46 | 2.62E-06 | DSS |
| 75646 | Rai14 | retinoic acid induced 14 | 1.4 | 7.32 | 2.57E-02 | DSS |
| 18030 | Nfil3 | nuclear factor, interleukin 3, regulated | 1.29 | 9.42 | 8.39E-05 | DSS |
| 21990 | Tph1 | tryptophan hydroxylase 1 | 1.24 | 8.88 | 5.26E-08 | DSS |
| 11551 | Adra2a | adrenergic receptor, alpha 2a | 1.23 | 10.69 | 7.68E-03 | DSS |
| 76459 | Car12 | carbonic anyhydrase 12 | 1.16 | 10.38 | 1.94E-03 | DSS |
| 104158 | Ces1d | carboxylesterase 1D | 1.13 | 11.21 | 3.84E-02 | DSS |
| 242705 | E2f2 | E2F transcription factor 2 | 1.04 | 9.05 | 6.36E-05 | DSS |
| 66811 | Duoxa2 | dual oxidase maturation factor 2 | 1 | 9.91 | 1.01E-02 | DSS |
| 13170 | Dbp | D site albumin promoter binding protein | −3.68 | 11.05 | 4.09E-06 | DSS |
| 26914 | H2afy | H2A histone family, member Y | −2.57 | 8.71 | 3.93E-15 | DSS |
| 229599 | Gm129 | circadian associated repressor of transcription | −1.87 | 8.93 | 1.18E-06 | DSS |
| 225742 | St8sia5 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 | −1.65 | 9.07 | 4.46E-05 | DSS |
| 393082 | Mettl7a2 | methyltransferase like 7A2 | −1.64 | 9.63 | 9.21E-04 | DSS |
| 66184 | Rps4y2 | ribosomal protein S4-like | −1.44 | 8.43 | 4.32E-09 | DSS |
| 108017 | Fxyd4 | FXYD domain-containing ion transport regulator 4 | −1.42 | 10.23 | 2.94E-03 | DSS |
| 21685 | Tef | thyrotroph embryonic factor | −1.34 | 9.95 | 2.17E-03 | DSS |
| 217166 | Nr1d1 | nuclear receptor subfamily 1, group D, member 1 | −1.2 | 10.00 | 2.45E-02 | DSS |
| 53376 | Usp2 | ubiquitin specific peptidase 2 | −1.17 | 9.19 | 6.03E-05 | DSS |
| 12346 | Car1 | carbonic anhydrase 1 | −1.12 | 14.02 | 2.45E-02 | DSS |
| 17829 | Muc1 | mucin 1, transmembrane | −1.1 | 9.57 | 1.94E-03 | DSS |
| 13034 | Ctse | cathepsin E | −1.08 | 11.54 | 1.77E-03 | DSS |
| 20692 | Sparc | secreted acidic cysteine rich glycoprotein | −1.07 | 10.58 | 5.73E-03 | DSS |
| 192113 | Atp12a | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | −1.05 | 12.63 | 3.84E-02 | DSS |
| 380997 | Cyp2d12 | cytochrome P450, family 2, subfamily d, polypeptide 12 | −1.04 | 10.82 | 6.48E-05 | DSS |
| 56857 | Slc37a2 | solute carrier family 37, member 2 | −1.04 | 10.94 | 8.74E-03 | DSS |
The fourth column shows the Log2FC of adenocarcinoma, AOM-treated mucosa and DSS-treated mucosa, respectively, vs normal mucosa. The significance level is indicated by a corrected p-value.