Figure 2. Knockdown of DR5 increases cancer cell metastasis in vivo.

Both 801C-pLKO.1 and 801C-shDR5 cells were injected subcutaneously into nude mice. After approximately one month, the mice began to be sacrificed to collect lungs for evaluation of human cancer cell metastasis with H&E staining of lung slices. Primary tumor growth rates (A), lung metastasis incidences (B), and representative pictures of lung metastasis (C) are presented. The areas indicated by arrows are metastasized human cancer nodules.