Skip to main content
. 2015 Oct 21;6(38):41383–41397. doi: 10.18632/oncotarget.5510

Figure 5. SPC24 inhibition affected HCC cell adhesion, invasion, and apoptosis.

Figure 5

SPC24 inhibition by siRNA-2 dramatically reduced cell adhesive ratio in both SMMC-7721 and HepG2 cells A. The invasiveness was evaluated by Matrigel assay in which scrambled siRNA served as a control and the cell number represented the mean values per field (from at least five fields) from 3 independent experiments (right panel) (mean ± SD), the data showed that the invasion of SMMC-7721 B. and HepG2 C. cells transfected with siRNA-2 was dramatically inhibited. Additionally, cleaved caspase-3 (active form of caspase-3) in SMMC7721 and HepG2 cells was increased by transfection with siRNA-2 confirmed by Western blot D.