Table 1.

Summary results for the SNPS: rs1321311 (6p21), rs3824999 (11q13.4) and rs5934683 (Xp22.2) associated with CRC risk.

SNP	STUDY	ORa	95% CIb	P-value
rs1321311	Discovery	1.09	1.05-1.14	4.79×10−5
	Replication	1.09	1.05-1.14	5.74×10−6
	Japan	1.18	1.03-1.36	1.71×10−2
	Combined	1.10	1.07-1.13	1.14×10−10 (Phet = 0.55, I2 =0%)
rs3824999	Discovery	1.08	1.05-1.13	1.77×10−5
	Replication	1.07	1.04-1.11	2.06×10−5
	Japan	1.09	0.99-1.19	8.46×10−2
	Combined	1.08	1.05-1.10	3.65×10−10 (Phet = 0.05, I2 = 41%)
rs5934683	Discovery	1.08	1.04-1.12	8.19×10−5
	Replication	1.07	1.04-1.10	2.16×10−6
	Japan	1.04	0.93-1.16	5.38×10−1
	Combined	1.07	1.04-1.10	7.30×10−10 (Phet = 0.31, I2 = 13%)

^aOdds ratio.

^b95% Confidence Interval.