Table 2. Changes in Wnt signaling related gene expression levels during cochlear development and maturation analyzed by RT2 Profiler PCR Array.
| P0 vs E12.5 | P6 vs P0 | P30 vs P6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Up | Fold change | Down | Fold change | Up | Fold change | Down | Fold change | Up | Fold change | Down | Fold Change |
| Wnt6 | +10 | Ccnd1 | -3.6 | Wisp1 | +8.0 | Wnt11 | - 2.5 | Wnt2b | +3.4 | Sfrp2 | -28.6 |
| Dkk3 | +6.2 | Jun | -3.5 | Sfrp3 | +4.1 | Dkk3 | +2.8 | Wif1 | -4.4 | ||
| Fzd9 | +5.3 | Dvl1 | -2.7 | Wif1 | +3.2 | Wnt6 | +2.8 | Myc | -4.2 | ||
| Wif1 | +4.8 | Wnt4 | -2.4 | Wnt4 | +3.2 | Dvl1 | +2.3 | Lef1 | -3.2 | ||
| Wnt5a | +4.1 | Fzd7 | -2.2 | Fzd5 | +3.1 | Sfrp1 | -3.2 | ||||
| Wisp1 | +4.0 | Ctbp1 | -2.0 | Kremen1 | +3.0 | Ccnd1 | -3.1 | ||||
| Tcf7 | +2.8 | Lef1 | -2.0 | Sox17 | +2.6 | Vangl2 | -3.1 | ||||
| RhoU | +2.6 | Mapk8 | -2.0 | Dvl1 | +2.5 | Fzd1 | -2.8 | ||||
| Wnt9a | +2.1 | Fzd9 | +2.3 | Ccnd2 | -2.6 | ||||||
| Sfrp3 | +2.0 | Wnt5a | +2.3 | Wnt4 | -2.6 | ||||||
| Fzd6 | +2.2 | Nkd1 | -2.4 | ||||||||
| Nlk | +2.1 | Tcf7 | -2.3 | ||||||||
| Porcn | +2.1 | Wnt5b | -2.2 | ||||||||
| Dab2 | -2.1 | ||||||||||
| Prickle1 | -2.1 | ||||||||||
| Tle1 | -2.0 | ||||||||||