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. 2016 Feb 9;11(2):e0147334. doi: 10.1371/journal.pone.0147334

Fig 5. Mutant AKT1E17K accelerates tumor formation induced by chemical carcinogens.

Fig 5

A. Lung tumor multiplicity in R26-AKT1E17K infected with Ad-Cre (6 and 9 months after the treatment, respectively). Each point represents one mouse; bars represent means ± SD. **p<0.01, *p<0.05. B. Diameter of lung tumors generated by urethane in R26-AKT1E17K mice treated with increasing doses of Ad-Cre. Bars represent mean diameter of tumor ±SD. *p<0.05. C, D. Representative H&E staining of lung lesions developed in R26-AKT1E17K mice treated with solvent or Ad-Cre, as indicated, 9 months after urethane administration. E, F. Phosporylated AKT staining of lung lesions developed in R26-AKT1E17K mice treated with solvent or Ad-Cre, as indicated, 9 months after urethane administration. Magnification as indicated.