Table 2. Common whole blood DEG identified by different RNA-seq analysis platform in elderly subjects after a 28 day treatment with LGG.
| Analysis platform | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | Gene ID | Locus | Description | Location | Regulation direction | edgeR-NF | edgeR cpm0.1/all | DESeq2 | TSPM | ||||||||
| logFC | FC | padj | logFC | FC | padj | logFC | FC | padj | logFC | FC | padj | ||||||
| FCER2 | ENSG00000104921 | 19:7753643–7767032 | Fc fragment of IgE, low affinity II, receptor for (CD23) | Plasma Membrane | down | -0.77 | 1.71 | 0.047 * | -0.78 | 1.72 | 0.034 * | -0.78 | 1.72 | 0.008 * | -0.26 | 1.20 | 0.063 |
| LY86 | ENSG00000112799 | 6:6346697–6655216 | lymphocyte antigen 86 | Plasma Membrane | down | -0.59 | 1.51 | 0.084 | -0.60 | 1.52 | 0.052 * | -0.60 | 1.52 | 0.008 * | -0.18 | 1.13 | 0.067 |
| DYNLL1 | ENSG00000088986 | 12:120907652–120936296 | dynein, light chain, LC8-type 1 | Cytoplasm | down | -0.52 | 1.44 | 0.137 | -0.53 | 1.45 | 0.073 | -0.53 | 1.44 | 0.008 * | -0.18 | 1.13 | 0.060 |
| CD79B | ENSG00000007312 | 17:62006099–62009714 | CD79b molecule, immunoglobulin-associated beta | Plasma Membrane | down | -0.50 | 1.41 | 0.137 | -0.51 | 1.42 | 0.073 | -0.50 | 1.41 | 0.008 * | -0.18 | 1.13 | 0.073 |
| VPREB3 | ENSG00000128218 | 22:24094929–24096655 | pre-B lymphocyte 3 | Cytoplasm | down | -0.78 | 1.71 | 0.137 | -0.79 | 1.73 | 0.073 | -0.78 | 1.72 | 0.014 * | -0.25 | 1.19 | 0.081 |
| LGALS1 | ENSG00000100097 | 22:38071614–38075813 | lectin, galactoside-binding, soluble, 1 | Extracellular Space | down | -0.65 | 1.56 | 0.137 | -0.66 | 1.58 | 0.073 | -0.65 | 1.57 | 0.014 * | -0.22 | 1.16 | 0.081 |
| RNASE1 | ENSG00000129538 | 14:21269386–21271437 | ribonuclease, RNase A family, 1 (pancreatic) | Extracellular Space | down | -1.12 | 2.17 | 0.137 | -1.13 | 2.19 | 0.073 | -1.10 | 2.14 | NA | -0.37 | 1.29 | 0.065 |
| HLA-DRB1 | ENSG00000206306 | 6:32546545–32557625 | major histocompatibility complex, class II, DR beta 1 | Plasma Membrane | down | -0.48 | 1.39 | 0.140 | -0.49 | 1.40 | 0.082 | -0.49 | 1.40 | 0.012 * | -0.18 | 1.13 | 0.060 |
| ATP6V1F | ENSG00000128524 | 7:128470430–128550773 | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | Other | down | -0.50 | 1.42 | 0.145 | -0.51 | 1.43 | 0.082 | -0.51 | 1.42 | 0.013 * | -0.17 | 1.13 | 0.065 |
| HLA-DMB | ENSG00000241674 | HSCHR6_MHC_DBB:32880345–32898843 | major histocompatibility complex, class II, DM beta | Plasma Membrane | down | -0.43 | 1.34 | 0.145 | -0.44 | 1.36 | 0.082 | -0.44 | 1.36 | 0.013 * | -0.13 | 1.10 | 0.080 |
| LSMD1 | ENSG00000183011 | 17:7760002–7816078 | LSM domain containing 1 | Other | down | -0.62 | 1.54 | 0.137 | -0.64 | 1.55 | 0.082 | -0.63 | 1.55 | 0.014 * | -0.19 | 1.14 | 0.084 |
| PTRHD1 | ENSG00000184924 | 2:25012854–25142708 | peptidyl-tRNA hydrolase domain containing 1 | Other | down | -0.63 | 1.54 | 0.145 | -0.64 | 1.56 | 0.082 | -0.63 | 1.55 | 0.014 * | -0.19 | 1.14 | 0.089 |
| TIMM13 | ENSG00000099800 | 19:2389768–2456994 | translocase of inner mitochondrial membrane 13 homolog (yeast) | Cytoplasm | down | -0.50 | 1.42 | 0.145 | -0.51 | 1.43 | 0.082 | -0.51 | 1.42 | 0.014 * | -0.18 | 1.13 | 0.065 |
| AKR1A1 | ENSG00000117448 | 1:46016214–46035721 | aldo-keto reductase family 1, member A1 (aldehyde reductase) | Cytoplasm | down | -0.46 | 1.38 | 0.145 | -0.47 | 1.39 | 0.082 | -0.47 | 1.39 | 0.014 * | -0.15 | 1.11 | 0.069 |
| TPR | ENSG00000047410 | 1:186265404–186344825 | translocated promoter region, nuclear basket protein | Nucleus | up | 0.44 | 1.36 | 0.145 | 0.43 | 1.35 | 0.082 | 0.43 | 1.35 | 0.014 * | 0.15 | 1.11 | 0.063 |
| GSTO1 | ENSG00000148834 | 10:105995113–106027217 | glutathione S-transferase omega 1 | Cytoplasm | down | -0.52 | 1.44 | 0.145 | -0.53 | 1.45 | 0.082 | -0.53 | 1.44 | 0.015 * | -0.16 | 1.12 | 0.088 |
| CAPG | ENSG00000042493 | 2:85621345–85645555 | capping protein (actin filament), gelsolin-like | Nucleus | down | -0.48 | 1.39 | 0.145 | -0.49 | 1.40 | 0.082 | -0.48 | 1.39 | 0.015 * | -0.16 | 1.12 | 0.065 |
| MRPL11 | ENSG00000174547 | 11:66202545–66234209 | mitochondrial ribosomal protein L11 | Cytoplasm | down | -0.53 | 1.45 | 0.145 | -0.54 | 1.46 | 0.082 | -0.54 | 1.45 | 0.016 * | -0.17 | 1.12 | 0.083 |
| CFD | ENSG00000197766 | 19:859452–863569 | complement factor D (adipsin) | Extracellular Space | down | -0.80 | 1.74 | 0.137 | -0.81 | 1.75 | 0.082 | -0.80 | 1.74 | 0.017 * | -0.36 | 1.28 | 0.060 |
| POLE4 | ENSG00000115350 | 2:75185618–75197255 | polymerase (DNA-directed), epsilon 4, accessory subunit | Nucleus | down | -0.67 | 1.59 | 0.145 | -0.69 | 1.61 | 0.082 | -0.68 | 1.60 | 0.017 * | -0.20 | 1.15 | 0.102 |
| FAU | ENSG00000149806 | 11:64888099–64902004 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | Cytoplasm | down | -0.61 | 1.53 | 0.145 | -0.62 | 1.54 | 0.082 | -0.62 | 1.54 | 0.017 * | -0.19 | 1.14 | 0.093 |
| IFI27L2 | ENSG00000119632 | 14:94594115–94596590 | interferon, alpha-inducible protein 27-like 2 | Other | down | -0.67 | 1.59 | 0.145 | -0.68 | 1.60 | 0.082 | -0.67 | 1.59 | 0.018 * | -0.21 | 1.16 | 0.093 |
| UQCR11 | ENSG00000267059 | 19:1576676–1605483 | ubiquinol-cytochrome c reductase, complex III subunit XI | Cytoplasm | down | -0.64 | 1.56 | 0.145 | -0.65 | 1.57 | 0.082 | -0.64 | 1.56 | 0.018 * | -0.20 | 1.14 | 0.094 |
| NAGK | ENSG00000124357 | 2:71163011–71306935 | N-acetylglucosamine kinase | Cytoplasm | down | -0.57 | 1.48 | 0.145 | -0.58 | 1.50 | 0.082 | -0.58 | 1.49 | 0.018 * | -0.16 | 1.12 | 0.093 |
| ROMO1 | ENSG00000125995 | 20:34213952–34288906 | reactive oxygen species modulator 1 | Cytoplasm | down | -0.63 | 1.55 | 0.145 | -0.64 | 1.56 | 0.082 | -0.64 | 1.56 | 0.019 * | -0.21 | 1.15 | 0.083 |
| PRDX4 | ENSG00000123131 | X:23682378–23704516 | peroxiredoxin 4 | Cytoplasm | down | -0.59 | 1.50 | 0.145 | -0.60 | 1.52 | 0.082 | -0.59 | 1.51 | 0.019 * | -0.19 | 1.14 | 0.093 |
| CD52 | ENSG00000169442 | 1:26605666–26647014 | CD52 molecule | Plasma Membrane | down | -0.86 | 1.82 | 0.145 | -0.88 | 1.84 | 0.082 | -0.86 | 1.82 | 0.019 * | -0.25 | 1.19 | 0.123 |
| ERN1 | ENSG00000178607 | 17:62120352–62207504 | endoplasmic reticulum to nucleus signaling 1 | Cytoplasm | up | 0.95 | 1.93 | 0.145 | 0.94 | 1.91 | 0.082 | 0.93 | 1.91 | 0.02 * | 0.34 | 1.27 | 0.066 |
| ATP5H | ENSG00000167863 | 17:73028669–73061984 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d | Other | down | -0.59 | 1.50 | 0.145 | -0.60 | 1.52 | 0.082 | -0.59 | 1.51 | 0.02 * | -0.18 | 1.14 | 0.093 |
| VAMP8 | ENSG00000118640 | 2:85788684–85809154 | vesicle-associated membrane protein 8 | Plasma Membrane | down | -0.59 | 1.51 | 0.145 | -0.61 | 1.52 | 0.082 | -0.60 | 1.52 | 0.02 * | -0.18 | 1.13 | 0.103 |
| RNASE6 | ENSG00000169413 | 14:21249209–21250626 | ribonuclease, RNase A family, k6 | Extracellular Space | down | -0.63 | 1.54 | 0.145 | -0.64 | 1.56 | 0.082 | -0.63 | 1.55 | 0.02 * | -0.21 | 1.16 | 0.083 |
| NBPF14 | ENSG00000122497 | 1:148003641–148025863 | neuroblastoma breakpoint family, member 15 | Other | up | 0.71 | 1.64 | 0.145 | 0.70 | 1.62 | 0.082 | 0.69 | 1.61 | 0.026 * | 0.25 | 1.19 | 0.081 |
| RPS15A | ENSG00000134419 | 16:18792616–18813000 | ribosomal protein S15a | Cytoplasm | down | -0.96 | 1.95 | 0.145 | -0.98 | 1.97 | 0.082 | -0.96 | 1.95 | 0.026 * | -0.28 | 1.22 | 0.145 |
| RPL35 | ENSG00000136942 | 9:127615754–127624260 | ribosomal protein L35 | Cytoplasm | down | -0.72 | 1.64 | 0.145 | -0.73 | 1.66 | 0.082 | -0.72 | 1.65 | 0.027 * | -0.22 | 1.16 | 0.118 |
| SIGLEC11 | ENSG00000161640 | 19:50392910–50464429 | sialic acid binding Ig-like lectin 11 | Plasma Membrane | down | -0.95 | 1.93 | 0.145 | -0.96 | 1.94 | 0.082 | -0.95 | 1.93 | NA | -0.36 | 1.29 | 0.072 |
| C1orf132 | ENSG00000203709 | 1:207986904–208042495 | Chromosome 1 open reading frame 32 | up | 1.02 | 2.03 | 0.145 | 1.01 | 2.01 | 0.082 | 1.00 | 2.00 | NA | 0.42 | 1.34 | 0.067 | |
| ZNF593 | ENSG00000142684 | 1:26496361–26498551 | zinc finger protein 593 | Nucleus | down | -0.69 | 1.61 | 0.145 | -0.70 | 1.62 | 0.082 | -0.69 | 1.61 | NA | -0.26 | 1.20 | 0.066 |
| SFTPD | ENSG00000133661 | 10:81664653–81742370 | surfactant protein D | Extracellular Space | down | -0.76 | 1.69 | 0.145 | -0.76 | 1.69 | 0.082 | -0.75 | 1.68 | NA | -0.22 | 1.16 | 0.083 |
| ATP5G3 | ENSG00000154518 | 2:176040985–176049335 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) | Cytoplasm | down | -0.38 | 1.30 | 0.147 | -0.39 | 1.31 | 0.085 | -0.39 | 1.31 | 0.008 * | -0.13 | 1.09 | 0.060 |
| C11orf31 | ENSG00000211450 | 11:57480071–57587018 | chromosome 11 open reading frame 31 | Nucleus | down | -0.55 | 1.47 | 0.145 | -0.57 | 1.48 | 0.085 | -0.56 | 1.47 | 0.018 * | -0.19 | 1.14 | 0.083 |
| CHCHD2 | ENSG00000106153 | 7:56169261–56174269 | coiled-coil-helix-coiled-coil-helix domain containing 2 | Cytoplasm | down | -0.47 | 1.38 | 0.145 | -0.48 | 1.39 | 0.085 | -0.48 | 1.39 | 0.018 * | -0.15 | 1.11 | 0.083 |
| FLVCR1 | ENSG00000162769 | 1:213031596–213072705 | feline leukemia virus subgroup C cellular receptor 1 | Plasma Membrane | up | 0.57 | 1.48 | 0.145 | 0.55 | 1.47 | 0.085 | 0.55 | 1.46 | 0.02 * | 0.24 | 1.18 | 0.065 |
| LILRB4 | ENSG00000186818 | 19:55155339–55181810 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 | Plasma Membrane | down | -0.54 | 1.46 | 0.145 | -0.55 | 1.47 | 0.085 | -0.55 | 1.46 | 0.02 * | -0.18 | 1.13 | 0.082 |
| RPL15 | ENSG00000174748 | 3:23933150–24021237 | ribosomal protein L15 | Cytoplasm | down | -0.49 | 1.40 | 0.145 | -0.50 | 1.41 | 0.085 | -0.50 | 1.41 | 0.02 * | -0.16 | 1.12 | 0.083 |
| PRRC2C | ENSG00000117523 | 1:171454650–171562650 | proline-rich coiled-coil 2C | Cytoplasm | up | 0.50 | 1.41 | 0.145 | 0.49 | 1.40 | 0.085 | 0.49 | 1.40 | 0.02 * | 0.16 | 1.12 | 0.067 |
| CHI3L2 | ENSG00000064886 | 1:111729795–111786062 | chitinase 3-like 2 | Extracellular Space | down | -0.80 | 1.74 | 0.145 | -0.81 | 1.76 | 0.085 | -0.80 | 1.74 | 0.028 * | -0.37 | 1.29 | 0.072 |
| NDUFA4 | ENSG00000065518 | 3:120315155–120321347 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa | Cytoplasm | down | -0.87 | 1.83 | 0.145 | -0.89 | 1.85 | 0.085 | -0.87 | 1.83 | 0.029 * | -0.25 | 1.19 | 0.143 |
| RPL27 | ENSG00000131469 | 17:41150289–41154976 | ribosomal protein L27 | Cytoplasm | down | -0.84 | 1.79 | 0.145 | -0.86 | 1.81 | 0.085 | -0.84 | 1.79 | 0.029 * | -0.25 | 1.19 | 0.147 |
| RPS21 | ENSG00000171858 | 1:150266288–150281414 | ribosomal protein S21 | Cytoplasm | down | -0.76 | 1.70 | 0.145 | -0.78 | 1.71 | 0.085 | -0.77 | 1.71 | 0.03 * | -0.23 | 1.17 | 0.135 |
| CBLN3 | ENSG00000139899 | 14:24895737–24912111 | cerebellin 3 precursor | Extracellular Space | down | -0.63 | 1.55 | 0.145 | -0.64 | 1.56 | 0.085 | -0.63 | 1.55 | NA | -0.17 | 1.12 | 0.093 |
| CCDC106 | ENSG00000173581 | 19:56146381–56164527 | coiled-coil domain containing 106 | Extracellular Space | down | -0.61 | 1.53 | 0.145 | -0.62 | 1.54 | 0.086 | -0.61 | 1.53 | 0.017 * | -0.22 | 1.17 | 0.065 |
| C12orf57 | ENSG00000111678 | 12:7052140–7055166 | chromosome 12 open reading frame 57 | Other | down | -0.58 | 1.50 | 0.145 | -0.59 | 1.51 | 0.086 | -0.59 | 1.51 | 0.026 * | -0.20 | 1.15 | 0.087 |
| BRK1 | ENSG00000254999 | 3:10157275–10168874 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | Cytoplasm | down | -0.46 | 1.38 | 0.145 | -0.48 | 1.39 | 0.086 | -0.47 | 1.39 | 0.019 * | -0.14 | 1.10 | 0.093 |
| RNASE3 | ENSG00000064886 | 14:21359557–21360507 | ribonuclease, RNase A family, 3 | Extracellular Space | down | -0.92 | 1.89 | 0.145 | -0.94 | 1.92 | 0.087 | -0.94 | 1.92 | 0.026 * | -0.28 | 1.21 | 0.093 |
| C17orf79 | ENSG00000172301 | 17:30178882–30186356 | coordinator of PRMT5, differentiation stimulator | Nucleus | down | -0.50 | 1.42 | 0.145 | -0.51 | 1.43 | 0.087 | -0.51 | 1.42 | 0.014 * | -0.18 | 1.13 | 0.063 |
| PRADC1 | ENSG00000135617 | 2:73455133–73460366 | protease-associated domain containing 1 | Extracellular Space | down | -0.50 | 1.41 | 0.145 | -0.51 | 1.42 | 0.087 | -0.50 | 1.41 | 0.014 * | -0.18 | 1.13 | 0.065 |
| C10orf125 | 10:98741040–98745582 | fucose mutarotase | Other | down | -0.53 | 1.44 | 0.145 | -0.54 | 1.45 | 0.087 | -0.54 | 1.45 | 0.015 * | -0.18 | 1.13 | 0.074 | |
| FAM96B | ENSG00000166595 | 16:66965958–66968326 | family with sequence similarity 96, member B | Cytoplasm | down | -0.46 | 1.38 | 0.145 | -0.48 | 1.39 | 0.087 | -0.47 | 1.39 | 0.018 * | -0.16 | 1.12 | 0.077 |
| HLA-DMA | ENSG00000204257 | 6:32902405–32949282 | major histocompatibility complex, class II, DM alpha | Plasma Membrane | down | -0.44 | 1.36 | 0.145 | -0.45 | 1.37 | 0.087 | -0.45 | 1.37 | 0.018 * | -0.15 | 1.11 | 0.081 |
| MT-ND3 | ENSG00000198840 | MT:10058–10404 | NADH dehydrogenase, subunit 3 (complex I) | Cytoplasm | down | -0.55 | 1.46 | 0.145 | -0.56 | 1.47 | 0.087 | -0.55 | 1.46 | 0.02 * | -0.21 | 1.16 | 0.066 |
| LSM7 | ENSG00000130332 | 19:2321519–2328615 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | Nucleus | down | -0.64 | 1.55 | 0.145 | -0.65 | 1.57 | 0.087 | -0.64 | 1.56 | 0.028 * | -0.20 | 1.15 | 0.100 |
| COX4I1 | ENSG00000131143 | 16:85805363–85840650 | cytochrome c oxidase subunit IV isoform 1 | Cytoplasm | down | -0.56 | 1.48 | 0.145 | -0.58 | 1.49 | 0.087 | -0.57 | 1.48 | 0.028 * | -0.17 | 1.13 | 0.102 |
| UBL5 | ENSG00000198258 | 19:9938567–9940791 | ubiquitin-like 5 | Cytoplasm | down | -0.57 | 1.48 | 0.145 | -0.58 | 1.50 | 0.087 | -0.57 | 1.48 | 0.029 * | -0.16 | 1.12 | 0.144 |
| RPS18 | ENSG00000096150 | HSCHR6_MHC_QBL:33129804–33173129 | ribosomal protein S18 | Cytoplasm | down | -0.74 | 1.67 | 0.145 | -0.75 | 1.68 | 0.087 | -0.74 | 1.67 | 0.029 * | -0.22 | 1.16 | 0.151 |
| COX7A2 | ENSG00000112695 | 6:75947390–75960039 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | Cytoplasm | down | -0.59 | 1.51 | 0.148 | -0.61 | 1.52 | 0.087 | -0.60 | 1.52 | 0.03 * | -0.17 | 1.12 | 0.147 |
| RPL35A | ENSG00000182899 | 3:197615945–197687013 | ribosomal protein L35a | Cytoplasm | down | -0.75 | 1.69 | 0.145 | -0.77 | 1.70 | 0.087 | -0.76 | 1.69 | 0.032 * | -0.24 | 1.18 | 0.138 |
| TCL1A | ENSG00000100721 | 14:96176303–96223993 | T-cell leukemia/lymphoma 1A | Nucleus | down | -0.76 | 1.70 | 0.145 | -0.77 | 1.71 | 0.087 | -0.77 | 1.71 | 0.033 * | -0.28 | 1.21 | 0.106 |
| SLC35E2 | ENSG00000189339 | 1:1634168–1677431 | solute carrier family 35, member E2 | Other | up | 0.71 | 1.64 | 0.145 | 0.70 | 1.63 | 0.087 | 0.70 | 1.62 | NA | 0.24 | 1.18 | 0.081 |
| GLIS3 | ENSG00000107249 | 9:3824126–4348392 | GLIS family zinc finger 3 | Nucleus | up | 1.05 | 2.06 | 0.156 | 1.04 | 2.05 | 0.087 | 1.02 | 2.03 | NA | 0.41 | 1.33 | 0.083 |
| PXMP2 | ENSG00000176894 | 12:133200344–133532892 | peroxisomal membrane protein 2, 22kDa | Cytoplasm | down | -0.63 | 1.55 | 0.159 | -0.64 | 1.56 | 0.087 | -0.63 | 1.55 | NA | -0.19 | 1.14 | 0.093 |
| C1orf98 | ENSG00000203721 | 1:200311671–200343482 | long intergenic non-protein coding RNA 862 | Other | up | 0.76 | 1.70 | 0.147 | 0.75 | 1.69 | 0.087 | 0.75 | 1.68 | NA | 0.24 | 1.18 | 0.083 |
| COMMD9 | ENSG00000110442 | 11:36295050–36310999 | COMM domain containing 9 | Other | down | -0.40 | 1.32 | 0.156 | -0.41 | 1.33 | 0.088 | -0.41 | 1.33 | 0.015 * | -0.13 | 1.09 | 0.073 |
| MPDU1 | ENSG00000129255 | 17:7465191–7536700 | mannose-P-dolichol utilization defect 1 | Cytoplasm | down | -0.41 | 1.33 | 0.156 | -0.42 | 1.34 | 0.088 | -0.42 | 1.34 | 0.016 * | -0.14 | 1.10 | 0.066 |
| NDUFB9 | ENSG00000147684 | 8:125500725–125740730 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | Cytoplasm | down | -0.43 | 1.34 | 0.145 | -0.44 | 1.35 | 0.088 | -0.43 | 1.35 | 0.017 * | -0.13 | 1.10 | 0.081 |
| RNASEH2C | ENSG00000172922 | 11:65479466–65488418 | ribonuclease H2, subunit C | Other | down | -0.45 | 1.37 | 0.145 | -0.46 | 1.38 | 0.088 | -0.46 | 1.38 | 0.017 * | -0.16 | 1.12 | 0.067 |
| EIF4EBP1 | ENSG00000187840 | 8:37887858–37917883 | eukaryotic translation initiation factor 4E binding protein 1 | Cytoplasm | down | -0.49 | 1.41 | 0.145 | -0.50 | 1.42 | 0.088 | -0.50 | 1.41 | 0.019 * | -0.17 | 1.13 | 0.072 |
| TRERF1 | ENSG00000124496 | 6:42192668–42419789 | transcriptional regulating factor 1 | Nucleus | up | 0.44 | 1.36 | 0.151 | 0.43 | 1.35 | 0.088 | 0.43 | 1.35 | 0.02 * | 0.16 | 1.12 | 0.072 |
| ASGR1 | ENSG00000141505 | 17:7076749–7082883 | asialoglycoprotein receptor 1 | Plasma Membrane | down | -0.51 | 1.42 | 0.152 | -0.52 | 1.43 | 0.088 | -0.51 | 1.42 | 0.02 * | -0.17 | 1.13 | 0.082 |
| SF3B5 | ENSG00000169976 | 6:144416017–144416754 | splicing factor 3b, subunit 5, 10kDa | Nucleus | down | -0.46 | 1.38 | 0.149 | -0.47 | 1.39 | 0.088 | -0.47 | 1.39 | 0.025 * | -0.15 | 1.11 | 0.083 |
| SERF2 | ENSG00000140264 | 15:44019115–44095241 | small EDRK-rich factor 2 | other | down | -0.50 | 1.42 | 0.145 | -0.51 | 1.43 | 0.088 | -0.51 | 1.42 | 0.026 * | -0.18 | 1.13 | 0.093 |
| GADD45GIP1 | ENSG00000179271 | 9:92219927–92221470 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | Nucleus | down | -0.54 | 1.45 | 0.145 | -0.55 | 1.46 | 0.088 | -0.54 | 1.45 | 0.026 * | -0.19 | 1.14 | 0.083 |
| GPX4 | ENSG00000167468 | 19:1103935–1106787 | glutathione peroxidase 4 | Cytoplasm | down | -0.48 | 1.40 | 0.145 | -0.49 | 1.41 | 0.088 | -0.49 | 1.40 | 0.026 * | -0.17 | 1.13 | 0.077 |
| TMEM141 | ENSG00000244187 | 7:134671258–134855547 | transmembrane protein 141 | Other | down | -0.52 | 1.43 | 0.147 | -0.53 | 1.44 | 0.088 | -0.52 | 1.43 | 0.026 * | -0.18 | 1.13 | 0.081 |
| UPF2 | ENSG00000151461 | 10:11962020–12085169 | UPF2 regulator of nonsense transcripts homolog (yeast) | Cytoplasm | up | 0.46 | 1.38 | 0.156 | 0.45 | 1.36 | 0.088 | 0.45 | 1.37 | 0.026 * | 0.17 | 1.12 | 0.069 |
| C19orf53 | ENSG00000104979 | 19:13875345–13889276 | chromosome 19 open reading frame 53 | Other | down | -0.51 | 1.42 | 0.145 | -0.52 | 1.43 | 0.088 | -0.51 | 1.42 | 0.028 * | -0.18 | 1.13 | 0.083 |
| C6orf108 | ENSG00000112667 | 6:43193366–43197222 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Nucleus | down | -0.59 | 1.50 | 0.156 | -0.60 | 1.52 | 0.088 | -0.59 | 1.51 | 0.028 * | -0.20 | 1.15 | 0.093 |
| UQCR10 | ENSG00000184076 | 22:30163357–30166402 | ubiquinol-cytochrome c reductase, complex III subunit X | Cytoplasm | down | -0.51 | 1.42 | 0.152 | -0.52 | 1.44 | 0.088 | -0.52 | 1.43 | 0.029 * | -0.16 | 1.12 | 0.093 |
| RNASE2 | ENSG00000169385 | 14:21423610–21424595 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | Cytoplasm | down | -0.79 | 1.73 | 0.156 | -0.81 | 1.75 | 0.088 | -0.81 | 1.75 | 0.032 * | -0.27 | 1.21 | 0.083 |
| MLL2 | ENSG00000167548 | 12:49388931–49453557 | up | 0.51 | 1.43 | 0.156 | 0.50 | 1.42 | 0.088 | 0.50 | 1.41 | 0.032 * | 0.19 | 1.14 | 0.083 | ||
| IL18R1 | ENSG00000115604 | 2:102927961–103015218 | interleukin 18 receptor 1 | Plasma Membrane | up | 0.59 | 1.50 | 0.152 | 0.57 | 1.49 | 0.088 | 0.57 | 1.48 | 0.032 * | 0.24 | 1.18 | 0.069 |
| COX7C | ENSG00000127184 | 5:85913720–85916779 | cytochrome c oxidase subunit VIIc | Cytoplasm | down | -0.84 | 1.79 | 0.156 | -0.86 | 1.82 | 0.088 | -0.85 | 1.80 | 0.038 * | -0.26 | 1.19 | 0.164 |
| IFITM3 | ENSG00000142089 | 11:319668–321340 | interferon induced transmembrane protein 3 | Plasma Membrane | down | -0.85 | 1.80 | 0.156 | -0.86 | 1.82 | 0.088 | -0.83 | 1.78 | 0.038 * | -0.24 | 1.18 | 0.102 |
| FUT10 | ENSG00000172728 | 8:33228341–33371119 | fucosyltransferase 10 (alpha (1,3) fucosyltransferase) | Cytoplasm | up | 0.88 | 1.84 | 0.147 | 0.87 | 1.83 | 0.088 | 0.86 | 1.82 | NA | 0.37 | 1.29 | 0.069 |
| COCH | ENSG00000100473 | 14:31343719–31562818 | cochlin | Extracellular Space | up | 0.77 | 1.71 | 0.156 | 0.76 | 1.70 | 0.088 | 0.75 | 1.68 | NA | 0.22 | 1.16 | 0.098 |
| ESM1 | ENSG00000164283 | 5:54273691–54330398 | endothelial cell-specific molecule 1 | Extracellular Space | up | 0.90 | 1.87 | 0.163 | 0.89 | 1.85 | 0.088 | 0.88 | 1.84 | NA | 0.34 | 1.26 | 0.083 |
| MZT2B | ENSG00000152082 | 2:130908980–130948302 | mitotic spindle organizing protein 2B | Cytoplasm | down | -0.55 | 1.46 | 0.148 | -0.55 | 1.47 | 0.089 | -0.55 | 1.46 | 0.029 * | -0.20 | 1.15 | 0.079 |
| MRPL23 | ENSG00000214026 | 11:1968507–2011150 | mitochondrial ribosomal protein L23 | Cytoplasm | down | -0.44 | 1.36 | 0.156 | -0.45 | 1.37 | 0.089 | -0.45 | 1.37 | 0.018 * | -0.14 | 1.10 | 0.083 |
| SYNE2 | ENSG00000054654 | 14:64319682–64805317 | spectrin repeat containing, nuclear envelope 2 | Nucleus | up | 0.62 | 1.53 | 0.159 | 0.60 | 1.52 | 0.089 | 0.60 | 1.52 | 0.037 * | 0.22 | 1.17 | 0.093 |
| LYPD2 | ENSG00000197353 | 8:143831567–143833952 | LY6/PLAUR domain containing 2 | Other | down | -0.62 | 1.54 | 0.161 | -0.63 | 1.55 | 0.089 | -0.63 | 1.55 | NA | -0.19 | 1.14 | 0.083 |
| RBX1 | ENSG00000100387 | 22:41253080–41369313 | ring-box 1, E3 ubiquitin protein ligase | Cytoplasm | down | -0.81 | 1.76 | 0.164 | -0.83 | 1.78 | 0.089 | -0.82 | 1.77 | 0.036 * | -0.25 | 1.19 | 0.129 |
| RPSA | ENSG00000168028 | 3:39448179–39453929 | ribosomal protein SA | Cytoplasm | down | -0.50 | 1.42 | 0.156 | -0.52 | 1.43 | 0.090 | -0.51 | 1.42 | 0.029 * | -0.17 | 1.13 | 0.094 |
| RPS9 | ENSG00000170889 | 19:54704609–54752862 | ribosomal protein S9 | Cytoplasm | down | -0.58 | 1.49 | 0.145 | -0.59 | 1.51 | 0.091 | -0.58 | 1.49 | 0.029 * | -0.20 | 1.15 | 0.093 |
| RPS5 | ENSG00000083845 | 2:95752951–95831158 | ribosomal protein S5 | Other | down | -0.53 | 1.44 | 0.145 | -0.54 | 1.45 | 0.091 | -0.53 | 1.44 | 0.028 * | -0.18 | 1.13 | 0.089 |
| RAB34 | ENSG00000109113 | 17:27041298–27045447 | RAB34, member RAS oncogene family | Cytoplasm | down | -0.42 | 1.34 | 0.159 | -0.43 | 1.35 | 0.092 | -0.43 | 1.35 | 0.015 * | -0.14 | 1.10 | 0.077 |
| BLOC1S1 | ENSG00000135441 | 12:56075329–56118489 | biogenesis of lysosomal organelles complex-1, subunit 1 | Cytoplasm | down | -0.52 | 1.44 | 0.156 | -0.54 | 1.45 | 0.092 | -0.53 | 1.44 | 0.026 * | -0.15 | 1.11 | 0.100 |
| RPLP0 | ENSG00000089157 | 12:120634488–120639038 | ribosomal protein, large, P0 | Cytoplasm | down | -0.49 | 1.40 | 0.145 | -0.50 | 1.41 | 0.092 | -0.50 | 1.41 | 0.024 * | -0.16 | 1.12 | 0.093 |
| BOD1L | ENSG00000038219 | 4:13570361–13629347 | biorientation of chromosomes in cell division 1-like 1 | Extracellular Space | up | 0.64 | 1.55 | 0.166 | 0.62 | 1.54 | 0.092 | 0.62 | 1.54 | 0.042 * | 0.23 | 1.17 | 0.083 |
| PNOC | ENSG00000168081 | 8:28107579–28200872 | prepronociceptin | Extracelular space | down | -0.49 | 1.40 | 0.171 | -0.50 | 1.41 | 0.094 | -0.50 | 1.41 | 0.014 * | -0.17 | 1.13 | 0.069 |
| NCOA1 | ENSG00000084676 | 2:24714782–24993571 | nuclear receptor coactivator 1 | Nucleus | up | 0.53 | 1.44 | 0.164 | 0.52 | 1.43 | 0.094 | 0.52 | 1.43 | 0.037 * | 0.19 | 1.14 | 0.083 |
| ZCCHC6 | ENSG00000083223 | 9:88902647–88969369 | zinc finger, CCHC domain containing 6 | Other | up | 0.57 | 1.48 | 0.166 | 0.56 | 1.47 | 0.094 | 0.55 | 1.46 | 0.04 * | 0.21 | 1.16 | 0.083 |
| LGALS2 | ENSG00000100079 | 22:37966254–37978623 | lectin, galactoside-binding, soluble, 2 | Cytoplasm | down | -0.76 | 1.69 | 0.166 | -0.78 | 1.71 | 0.094 | -0.76 | 1.69 | 0.042 * | -0.16 | 1.12 | 0.207 |
| CLEC11A | ENSG00000105472 | 19:51226585–51228974 | C-type lectin domain family 11, member A | Extracellular Space | down | -0.68 | 1.60 | 0.163 | -0.69 | 1.61 | 0.094 | -0.68 | 1.60 | NA | -0.32 | 1.25 | 0.065 |
| VAMP5 | ENSG00000168899 | 2:85811530–85820535 | Vesicle associated membrane protein | Plasma Membrane | down | -0.53 | 1.44 | 0.166 | -0.54 | 1.45 | 0.095 | -0.53 | 1.44 | 0.034 * | -0.17 | 1.13 | 0.094 |
| BCL2L11 | ENSG00000153094 | 2:111876954–111924587 | BCL2-like 11 (apoptosis facilitator) | Cytoplasm | up | 0.59 | 1.51 | 0.166 | 0.58 | 1.50 | 0.095 | 0.58 | 1.49 | 0.039 * | 0.21 | 1.16 | 0.088 |
| ECI1 | ENSG00000167969 | 16:2289395–2302301 | Enoyl-CoA delta isomerase 1 | Cytoplasm | down | -0.45 | 1.36 | 0.161 | -0.46 | 1.37 | 0.095 | -0.45 | 1.37 | 0.02 * | -0.15 | 1.11 | 0.074 |
| MGMT | ENSG00000170430 | 10:131265447–131566271 | O-6 methylguanine-DNA methyl-transferase | Nucleus | down | -0.48 | 1.39 | 0.156 | -0.49 | 1.40 | 0.095 | -0.48 | 1.39 | 0.021 * | -0.17 | 1.12 | 0.067 |
| C11orf51 | anaphase promoting complex subunit 15 | Other | down | -0.52 | 1.44 | 0.164 | -0.54 | 1.45 | 0.095 | -0.53 | 1.44 | 0.028 * | -0.15 | 1.11 | 0.121 | ||
| TPPP3 | ENSG00000159713 | 16:67423711–67427438 | tubulin polymerization-promoting protein family member 3 | Other | down | -0.53 | 1.44 | 0.156 | -0.54 | 1.45 | 0.095 | -0.53 | 1.44 | 0.03 * | -0.16 | 1.12 | 0.110 |
| MFN2 | ENSG00000116688 | 1:12040237–12073571 | mitofusin 2 | Cytoplasm | up | 0.51 | 1.43 | 0.157 | 0.51 | 1.42 | 0.095 | 0.50 | 1.41 | 0.037 * | 0.19 | 1.14 | 0.088 |
| SIPA1L2 | ENSG00000116991 | 1:232533710–232697304 | signal-induced proliferation-associated 1 like 2 | Other | up | 0.59 | 1.50 | 0.159 | 0.58 | 1.49 | 0.095 | 0.58 | 1.49 | 0.038 * | 0.21 | 1.15 | 0.083 |
| KAT6A | ENSG00000083168 | 8:41786996–41909508 | K(lysine) acetyltransferase 6A | Nucleus | up | 0.52 | 1.43 | 0.166 | 0.51 | 1.42 | 0.095 | 0.51 | 1.42 | 0.039 * | 0.18 | 1.13 | 0.083 |
| HLA-DRA | ENSG00000204287 | 6:32407618–32412823 | Major Histocompatibility complex class II, DR alpha | Plasma Membrane | down | -0.47 | 1.38 | 0.145 | -0.48 | 1.39 | 0.096 | -0.48 | 1.39 | 0.017 * | -0.15 | 1.11 | 0.085 |
| C7orf50 | ENSG00000146540 | 7:1036622–1177896 | chromosome 7 open reading frame 50 | Other | down | -0.47 | 1.39 | 0.159 | -0.48 | 1.39 | 0.096 | -0.47 | 1.39 | 0.029 * | -0.17 | 1.12 | 0.083 |
| SSR4 | ENSG00000180879 | X:153051220–153063960 | Signal sequence receptor delta | Cytoplasm | down | -0.47 | 1.39 | 0.161 | -0.48 | 1.40 | 0.096 | -0.48 | 1.39 | 0.032 * | -0.16 | 1.12 | 0.083 |
| NDUFB7 | ENSG00000099795 | 19:14676889–14682874 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | Cytoplasm | down | -0.56 | 1.48 | 0.161 | -0.57 | 1.49 | 0.096 | -0.56 | 1.47 | 0.037 * | -0.20 | 1.15 | 0.093 |
| LIPC | ENSG00000166035 | 15:58245621–58861151 | Hepatic lipase | Extracellular Space | down | -0.77 | 1.71 | 0.181 | -0.78 | 1.72 | 0.096 | -0.77 | 1.71 | NA | -0.22 | 1.16 | 0.123 |
| SYCE1L | ENSG00000205078 | 16:77224731–77478233 | Synaptonemal complex central element protein 2 | Other | down | -0.81 | 1.75 | 0.181 | -0.81 | 1.76 | 0.096 | -0.80 | 1.74 | NA | -0.27 | 1.20 | 0.097 |
| RPS13 | ENSG00000110700 | 11:17095935–17229530 | Ribosomal protein S3 | Other | down | -0.54 | 1.45 | 0.156 | -0.55 | 1.46 | 0.097 | -0.54 | 1.45 | 0.036 * | -0.17 | 1.13 | 0.110 |
| CSTB | ENSG00000160213 | 21:45192392–45196326 | cystatin B (stefin B) | Cytoplasm | down | -0.39 | 1.31 | 0.166 | -0.40 | 1.32 | 0.098 | -0.40 | 1.32 | 0.017 * | -0.13 | 1.10 | 0.063 |
| S100A6 | ENSG00000197956 | 1:153506078–153508720 | S100 Calcium binding protein A6 | Cytoplasm | down | -0.46 | 1.37 | 0.145 | -0.47 | 1.38 | 0.098 | -0.46 | 1.38 | 0.022 * | -0.14 | 1.10 | 0.093 |
| C11orf73 | ENSG00000149196 | 11:86013252–86056969 | Chromosome 11 open reading frame 73 | cytoplasm | down | -0.45 | 1.37 | 0.181 | -0.47 | 1.38 | 0.098 | -0.46 | 1.38 | 0.026 * | -0.14 | 1.10 | 0.093 |
| MFSD9 | ENSG00000135953 | 2:103332298–103353347 | major facilitator superfamily domain containing 9 | Other | up | 0.53 | 1.44 | 0.161 | 0.52 | 1.43 | 0.098 | 0.51 | 1.42 | 0.03 * | 0.20 | 1.15 | 0.082 |
| LRRC24 | ENSG00000254402 | 8:145743375–145754516 | Leucine rich repeat containing 24 | other | down | -0.66 | 1.57 | 0.181 | -0.66 | 1.58 | 0.098 | -0.66 | 1.58 | NA | -0.20 | 1.15 | 0.002 |
| PLEKHM3 | ENSG00000178385 | 2:208693026–208890284 | Pleckstrin homology domain containing family M, member 3 | Other | up | 0.66 | 1.58 | 0.173 | 0.65 | 1.57 | 0.099 | 0.65 | 1.57 | NA | 0.25 | 1.19 | 0.073 |
| MRP63 | ENSG00000173141 | 13:21750783–21753223 | down | -0.43 | 1.35 | 0.170 | -0.45 | 1.36 | 0.099 | -0.44 | 1.36 | 0.02 * | -0.15 | 1.11 | 0.083 | ||
| ANAPC11 | ENSG00000141552 | 17:79845712–79869340 | Anaphase promoting complex subunit 11 | Cytoplasm | down | -0.45 | 1.37 | 0.166 | -0.46 | 1.38 | 0.099 | -0.46 | 1.38 | 0.026 * | -0.15 | 1.11 | 0.083 |
| ATP5J2 | ENSG00000241468 | 7:98923520–99063954 | ATP synthase, H+ transporting mitocondrial Fo complex, subunit F2 | Cytoplasm | down | -0.56 | 1.47 | 0.166 | -0.57 | 1.49 | 0.099 | -0.57 | 1.48 | 0.041 * | -0.18 | 1.13 | 0.119 |
| PLP2 | ENSG00000102007 | X:49028272–49042845 | proteolipid protein 2 (colonic epithelium-enriched) | Cytoplasm | down | -0.53 | 1.44 | 0.166 | -0.54 | 1.45 | 0.099 | -0.53 | 1.44 | 0.041 * | -0.18 | 1.14 | 0.096 |
| RPS29 | ENSG00000213741 | 14:50043389–50081390 | Ribosomalprotein S29 | Cytoplasm | down | -0.77 | 1.71 | 0.166 | -0.79 | 1.73 | 0.099 | -0.78 | 1.72 | 0.047 * | -0.24 | 1.18 | 0.167 |
Symbols not detected by DESEq2 are denoted in Italics.
* DEGs with an adjusted p-value< 0.05.