| MG-132 |
1 |
specific proteasome inhibitor reduces degradation of ubiquitin-conjugated proteins. Activates c-Jun N-terminal Kinase (JNK1) which initiates apoptosis and inhibits NF-kB activation. |
Antineoplastic, inhibit or prevent tumor proliferation, inhibits IL-1B/tumor necrosis factorα induced activation of Nuclear factor-ҝi |
| demecolcine |
0.95 |
Alkaloid, inhibitis mitosis at metaphase by inhibiting spindle formation |
Anti-neoplastic, improve results of cancer radiotherapy |
| emetine |
0.93 |
alkaloid, protein synthesis inhibitor in eukariotic cells |
Used as anti-protozoal and to induce vomiting. |
| 1,5-isoquinolinediol |
0.92 |
Inhibitor of PARP-1 and NOS2. |
Cell neuroprotective properties. PARP and NOS2 activations are implicated in deterious inflammatory responses and suppression of their activity has been correlated with to cellular protection and survival |
| cephaeline |
0.9 |
alkaloid |
Induces vomiting by stimulating the stomach lining, amoebicide. |
| MG-262 |
0.89 |
proteasome inhibitor |
MG-262 Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts. |
| decitabine |
0.88 |
antimetabolite, demethylation agent |
Decitabine is an anti-cancer "antineoplastic" or "cytotoxic" chemotherapy drug. |
| sulmazole |
0.85 |
A1 adenosine receptor antagonist |
An imidazopyridine that is 1H-imidazo[4,5-b]pyridine which is substituted at position 2 by a 2-methoxy-4-(methylsulfinyl)phenyl group. An A1 adenosine receptor antagonist, it was formerly used as a cardiotonic agent |
| chlortalidone |
0.84 |
thiazide diuretic |
For management of hypertension and edema. |
| tyrphostin AG-1478 |
0.84 |
inhibitor of EGFR tyrosine kinase activity |
Commonly use as an EGF signaling blocker. Inhibits cell proliferation and arrest cell cycle in tumor cells with overexpression of EGFR. |
| |
|
|
|
| H-7 |
-0.98 |
protein Kinase C inhibitor |
H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. This compound is shown to inhibit Topo I and II in murine L929 cells and induce apoptosis through PKC inhibition |
| Irinotecan |
-0.99 |
alkaloid, topoisomerase I inhibitor |
Anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase I inhibitor |
| Camptothecin |
-1 |
alkaloid |
Inhibits the nuclear enzyme DNA Topoisomerases, Type I. Anti-tumor activity |
| tyrphostin AG-825 |
-1 |
|
Selective ErbB2 inhibitor, Inhibit Her-2/neu signaling and promote killing of human LNCaP, C4, and C4-2 prostate cancer cells. |
