Table 2.

Final Results of Logistic Regression Analysis of Primary and Secondary Phenotypes Versus Genotyped and Imputed Single-Nucleotide Polymorphisms (SNPs), and Primary Phenotype vs Imputed HLA Serotype

Model, SNP	Chromosome	Gene	Location	A1	A2	OR	P Valuea
Primary phenotype (all S. aureus infections) SNP association model
Genotyped
rs4321864	6	HLA-DRA	5′ end of gene	A	C	1.13	8.8 × 10−8
Imputed
rs115231074	6	HLA-DRB1	Intergenic: 3′ downstream of –DRB1	T	C	1.22	1.3 × 10−10
rs35079132	6	HLA-DRB1	Intergenic	C	T	1.24	3.8 × 10−8
rs189516143	6	HLA-DRB1	Intergenic	A	T	1.21	9.2 × 10−8
rs190073676	6	HLA-DRB1	Intergenic	T	A	1.18	1.6 × 10−7
rs184932624	6	HLA-DRB1	Intergenic	T	C	1.23	2.5 × 10−7
rs17210959	6	HLA-DRB1	Within locus	A	G	1.23	3.5 × 10−7
Secondary phenotype (community-acquired SSTc S. aureus infections) SNP association model
Genotyped
rs4321864	6	HLA-DRA	5′ end of gene	A	C	1.14	8.1 × 10−5
Imputed
rs115231074	6	HLA-DRB1	Intergenic: 3′ downstream of –DRB1	T	C	1.28	5.2 × 10−8
rs12526396	6	…	Intergenic	G	A	0.80	4.3 × 10−7
Primary phenotype (all S. aureus infections) imputed HLA serotype association model
Imputed HLA serotype	…	…	…		…
HLA_DRB1_04	…	…	…	Present	…	1.08	.01
HLA_DRB1_0401	…	…	…	Present	…	1.08	.04
HLA_DRB1_0402	…	…	…	Present	…	1.36	.002

Analyses were adjusted for age, sex, and the first 10 eigenvectors from a principal components analysis.

Abbreviations: A1, minor allele; A2, major allele; OR, odds ratio; S. aureus, Staphylococcus aureus; SST, skin and soft tissue.

^a Threshold for genome-wide significance: P ≤ 5 × 10⁻⁸.