Table 2.

Anatomical location of clusters displayed in Figs 1 and 2 with detailed statistics

Anatomical location of the cluster	Hemisphere	Brodmann area / cerebellar lobule	MNI coordinates of global maxima			Cluster volume	T-value
			x	y	z
GM: ET<HV
Cerebellum	R	Lobule IV, V	21	−28	−24	63	4.83
	L	Lobule VIII	−27	−48	−56	797	4.34
GM: ET>HV
SMA	Bilateral	Medial BA 6	10	3	54	233	5.10
			−10	−1	60		3.87
Multiple regression GM in patients
Negative correlation with GM in left cerebellum
SMA proper	R	Medial BA 6	10	−20	57	194	3.70
Negative correlation with GM in right cerebellum
SMA proper	L	Medial BA 6	−10	−12	48	36	3.38
Positive correlation with disease duration
preSMA/SMA proper	R/bilateral		8	11	75	1150	3.76
Positive correlation with tremor frequency
Cerebellar vermis	Bilateral	VIII	2	−63	−39	967	3.80
Negative correlation with tremor frequency
SMA proper	R		15	−1	57	1653	6.10
	L		−18	0	66	407	3.12
ALFF: ET<HV
SMA	R	BA 6	10	10	58	2557	4.09
	L		−10	16	58		3.91
Multiple regression ALFF in essential tremor
Negative correlation with total B score
Precentral gyrus	R	BA 4,6	32	−20	72	2853	4.84
	L		−36	−12	51	2176	4.68
SMA	Bilateral	BA 6	0	−2	60	1288	4.20
Positive correlation with cerebellar GM
Precentral gyrus	L	BA 4,6	−32	−16	70	93	3.09
	R		36	−26	68	43	3.04
SMA	Bilateral	BA 6	2	2	60	34	2.94
Positive correlation with tremor frequency
Precentral gyrus	R	BA 4,6	36	−12	57	1085	4.09
	L		−30	−20	48	692	3.06
SMA	Bilateral	BA 6	3	−3	50	973	3.59

GM = grey matter; R = right; L = left; BA = Brodmann area; ET = essential tremor patients; HV = healthy volunteers. Global maxima without cluster volume are included in the cluster above.