Table 2.
Genome editing firstly reported in various biological systems and zebrafish
| Technology |
First report on genome editing |
First report on zebrafish |
|||||
|---|---|---|---|---|---|---|---|
| Gene/locus | Species/cell line | Time | Ref. | Gene | Time | Ref. | |
| ZFN | Yellow (y) | Drosophila | Jul, 2002 | [3] | gol | Jun, 2008 | [11] |
| TALENs | NTF3 and CCR5 | HEK 293, K562 | Feb, 2011 | [17] | tnikb | Aug, 2011 | [19] |
| CRISPR/Cas | AAVS1 locus | HEK 293, K562, and PGP1 iPS cells | Feb, 2013 | [29] | tia1l and gsk3b | Mar, 2013 | [33] |
| EMX1 | HEK 293 | Feb, 2013 | [28] | ||||
| Th loci | N2A | Feb, 2013 | [28] | ||||
Note: ZFN, zinc finger nuclease; TALEN, transcription activator-like effector nuclease; CRISPR, clustered regularly-interspaced short palindromic repeat; Cas, CRISPR-associated; NTDF3, neurotrophin-3; CCR5, chemokine (C–C motif) receptor 5; AAVS1, adeno-associated virus integration site 1; EMX1, empty spiracles homeobox 1; Th, tyrosine hydroxylase; gol, golden; tnikb, TRAF2 and NCK-interacting protein kinase; tia1, T-cell-restricted intracellular antigen-1; gsk3b, glycogen synthase kinase 3 beta.