Table 3.

Diffusion metrics estimates (mean ± standard error of the mean (SEM)) in each brain region of interest for the 8-month old mice.

		MD	D‖	D⊥	MK	K‖	K⊥
		μm2/ms	μm2/ms	μm2/ms
FC	NS	0.79 ± 0.06	0.92 ± 0.09	0.72 ± 0.05	0.75 ± 0.05	0.72 ± 0.04	0.75 ± 0.06
	TS	0.78 ± 0.02	0.92 ± 0.03	0.71 ± 0.02	0.68 ± 0.04	0.64 ± 0.05	0.66 ± 0.06
p-values		0.81	0.94	0.64	0.04	0.03	0.06
CT	NS	0.78 ± 0.02	0.88 ± 0.03	0.73 ± 0.02	0.75 ± 0.03	0.76 ± 0.03	0.78 ± 0.04
	TS	0.75 ± 0.01	0.86 ± 0.02	0.70 ± 0.02	0.72 ± 0.09	0.77 ± 0.09	0.70 ± 0.06
p-values		0.48	0.35	0.64	0.38	0.95	0.03
ST	NS	0.75 ± 0.02	0.91 ± 0.04	0.67 ± 0.02	0.86 ± 0.06	0.86 ± 0.05	0.97 ± 0.07
	TS	0.74 ± 0.02	0.88 ± 0.03	0.67 ± 0.01	0.80± 0.05	0.78 ± 0.06	0.86 ± 0.09
p-values		0.48	0.25	0.92	0.15	0.03	0.04
HT	NS	0.79 ± 0.01	0.88 ± 0.02	0.75 ± 0.01	0.81 ± 0.04	0.79 ± 0.02	0.83 ± 0.05
	TS	0.81 ± 0.02	0.90 ± 0.02	0.76 ± 0.01	0.71± 0.07	0.71 ± 0.10	0.71 ± 0.07
p-values		0.29	0.25	0.46	0.02*	0.07	0.01*
HD	NS	0.79 ± 0.01	0.87 ± 0.01	0.74 ± 0.01	0.82 ± 0.01	0.83 ± 0.01	0.85 ± 0.02
	TS	0.78 ± 0.01	0.87 ± 0.01	0.73 ± 0.00	0.69 ± 0.02	0.71 ± 0.02	0.70 ± 0.03
p-values		0.35	0.84	0.24	0.001*	0.001*	0.002*
HV	NS	0.79 ± 0.01	0.88 ± 0.02	0.75 ± 0.01	0.80 ± 0.02	0.77 ± 0.03	0.82 ± 0.03
	TS	0.81 ± 0.02	0.91 ± 0.02	0.76 ± 0.02	0.71 ± 0.04	0.71 ± 0.04	0.71 ± 0.04
p-values		0.40	0.22	0.52	0.06	0.26	0.07

Diffusion metrics estimates (mean ± standard error of the mean (SEM)) in each brain region of interest for the 8 months old mice. One-way ANOVA with significant p-values in bold; a (*) indicates that the group difference remained significant after applying Bonferroni correction. Mean diffusivity (MD); axial diffusivity (D_‖); radial diffusivity (D_⊥); mean kurtosis (MK); axial kurtosis (K_‖); radial kurtosis (K_⊥); Ts65Dn (TS; n=4) and normossomic control (NS; n=8) groups; frontal cortex (FC), cortex (CT), striatum (ST) and hippocampus (total – HT; dorsal – HD; ventral – HV)