Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Theoretical TS model for NSD2 methylation of H3K36. (A) A prediction of the lysine substrate geometry from the structure NSD1 overlaid with the with peptide substrates of SET7/9 (PDB ID codes 1XQH and 2F69) SET8 (PDB ID codes 3F9W and 3F9Y), and PIM5 (PDB ID code 1PEG) shown in cyan. (B) A simplified TS model for the NSD2 methyl-transfer reaction derived from the SAM and lysine geometry. (C) KIEs predicted for TS1 at different fixed C–N and C–S distances.
