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. 2016 Jan 19;113(5):1197–1201. doi: 10.1073/pnas.1521036113

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Fig. 4. — Geometry and electrostatic potential surface of the NSD2 TS structure. (A) TS structure for H3K36 methylation catalyzed by NSD2 with active-site amino acids F1117, M1140, and Y1179 (TS2). (B) Electrostatic potential surface map (EPSM) for TS2 (red, partial negative; blue, partial positive). (C) A comparison of the EPSM for TS2, SAM, and methyltransferase inhibitor sinefungin. The NBO charge for the sulfur atom, CH₃ group (sum of carbon and hydrogen), and lysine NH₂ group are shown in parentheses for TS2 and SAM.