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. 2016 Jan 19;113(5):1423–1428. doi: 10.1073/pnas.1524387113

Fig. 1.

Fig. 1.

Reduction of p11 in the dorsal striatum improves evoked motor behavior in adult mice. (A) Diagram of the experimental design. (B) Immunostaining demonstrating equivalent striatal AAV vector transduction based on YFP expression, with similar overall cell numbers based on staining for DARPP-32 and DAPI. (C) Knockdown of p11 in the dorsal striatum of adult mice increased endurance on the rotarod test. A significant increase in rotarod time was observed in AAV.sh.p11 mice just before the 6-OHDA lesion, and this increase was maintained after the lesion. *P < 0.05, sh.p11 relative to sh.Luc controls, two-tailed t test. (D) Striatal p11 reduction improved performance on the treadmill speed challenge after the 6-OHDA lesion compared with controls. *P < 0.05, **P < 0.01, sh.p11 relative to sh.Luc controls, two-tailed Fisher’s exact test. The numbers of mice per experimental group were as follows: no virus, n = 12; sh.Luc, n = 10; sh.P11, n = 11.