Fig. 3.

Reduction of p11 in the dorsal striatum decreases rotational turns in response to dopamine agonists in adult mice. (A) Diagram of the experimental design. (B–E) Contralateral rotations were decreased in animals with inhibition of striatal p11 ipsilateral to the 6-OHDA lesions compared with lesioned mice receiving a control AAV after administration of apomorphine (B), l-dopa (C), D1R agonist SKF81297 (D), and D2R agonist quinpirole (E). ***P < 0.001, ****P < 0.0001, sh.p11 relative to sh.Luc controls, two-tailed t test. The numbers of mice per group were as follows: no virus, n = 19; sh.Luc, n = 18; sh.P11, n = 18. The experiment was repeated three times.