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. 2016 Jan 19;113(5):1423–1428. doi: 10.1073/pnas.1524387113

Fig. 4.

Fig. 4.

Reduction of striatal p11 expression significantly reduces l-dopa-induced AIMs. (A) Diagram of the experimental design. (B) Individual AIM subscores per group in a single testing session. (C) Total AIMs composite score in a single testing session. (D–G) Individual AIM subscores per group across the entire 3 wk of daily l-dopa treatment. On day 14, the mice also received the 5-HT1B agonist CP94253. (H) Composite AIM scores of ALO subscores across the entire study. (I) Composite total AIM scores (ALO plus locomotor subscores) across the entire study. Administration of CP94253 to control mice modestly reduced AIMs by roughly 20% in all subscores and in total composite AIM scores compared with l-dopa alone, but this effect was not observed in AAV.sh.p11 mice. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, sh.p11 relative to sh.Luc controls; #P < 0.05, ##P < 0.01 for day 14 sh.Luc compared with either day 10 or day 16 for the same group. n = 18 sh.Luc mice; n = 17 sh.p11 mice. The experiment was repeated three times.