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. 2016 Jan 19;113(5):1321–1326. doi: 10.1073/pnas.1515137113

Fig. 1.

Fig. 1.

Enhancing DDT resistance by artificial selection or overexpression of Cyp6g1 in Malpighian tubules did not extend fly lifespan. (A) Both selection lines (selection A and selection B) showed significant DDT resistance compared with three control populations (control lines X, Y, and Z) that had been maintained in parallel under nonselection conditions. (B) Lifespans of the same lines as in A, in the absence of DDT. The DDT-selected lines were shorter-lived than controls (P < 0.005 in all comparisons of selection vs. control populations, log-rank test). (C and D) Uo-GAL4 drove expression of Cyp6g1 in Malpighian tubules. This intervention increased resistance to DDT (P = 0.040 for comparison with Uo-GAL4/+ and P = 0.001 for comparison with UAS-Cyp6g1-8a/+, log-rank test) (C) but did not affect longevity (D) (P > 0.3 for all experimental lines vs. controls, log-rank test).