Table S1.
Transcription factor binding sites found overrepresented in the promoters of genes with higher expression in the long-lived IIS mutant flies
| TRANSFAC | Drosophila TF binding to site | Function summary |
| AP-1 | Jra Kayak | Cytoskeletal rearrangement in development, immune response, wound healing |
| DR1 | PPAR ortholog unknown in flies | Control aspects of fat tissue formation and metabolism in mammals |
| Evi-1 | Putatively CG10348 and Hamlet | Neuronal development |
| GATA | Pnr, Srp, Grn, GATAd GATAe | Hematopoeisis, cardiac development, endoderm development and adult immunity |
| HNF4 | Hnf4 | CNS development |
| Pbx | Extradenticle | Developmental leg patterning |
| PXR | DHR96 | Req for normal regulation of detox enzymes |
| TFAM | mtTF A | mitDNA replication and maintenance |
| TTF1 | Putatively Vnd | Ventral nerve system development |
| Zeste | Zeste | Regulation of homeotic genes |
*
Known proteins or predicted orthologs of proteins binding to DNA element. See also Dataset S2.