Table S2.

Cox Proportional Hazard statistics

Relevant figure	Experiment	Coefficient	Estimate	SE	P value
Fig. 4A	Stress assay	dFOXO oe status	0.0967	0.0433	0.0237
	DDT	DHR96 status	0.4358	0.0441	<0.0001
		DHR96 status > dFOXO oe status	−0.1329	0.0433	0.0021
	Stress assay	dFOXO oe status	0.2411	0.0490	<0.0001
	Phenobarbital	DHR96 status	0.2622	0.0490	<0.0001
		DHR96 status > dFOXO oe status	−0.1377	0.0489	0.0046
	Stress assay	dFOXO oe status	0.0846	0.0506	0.0902
	Malathion	DHR96 status	0.4224	0.0511	<0.0001
		DHR96 status > dFOXO oe status	−0.1816	0.0507	0.0003
Fig. 4B	Stress assay	mNSC ablation status	−0.425	0.0727	<0.0001
	DDT	DHR96 status	0.9092	0.0730	<0.0001
		DHR96 status > mNSC status	0.5854	0.0726	<0.0001
	Stress assay	mNSC ablation status	−0.2000	0.0521	<0.0001
	Phenobarbital	DHR96 status	0.4428	0.053	<0.0001
		DHR96 status > mNSC status	0.2014	0.0508	<0.0001
	Stress assay	mNSC ablation status	−0.3484	0.0607	<0.0001
	Malathion	DHR96 status	0.3035	0.0586	<0.0001
		DHR96 status > mNSC status	0.2694	0.0599	<0.0001
Fig. 6A	Lifespan assay	dfoxo oe status	0.2583	0.0362	<0.001
		DHR96 status	0.2009	0.0362	<0.001
		DHR96 status > dfoxo oe status	0.0662	0.0356	0.0909
Fig. 6B	Lifespan assay	mNSC ablation status	−0.309	0.0383	<0.001
		DHR96 status	0.1518	0.0369	<0.001
		DHR96 status > mNSC status	−0.0377	0.0368	0.3055

Interaction was tested between the effect of reduced IIS [dFOXO overexpression (oe) status or mNSC ablation status] and the effect of DHR96 gene deletion (DHR96 status). The estimate of the coefficient states the natural log of the hazard ratio. A beneficial effect on survival is displayed by a negative value. “>” in column 3 indicates that interaction between two status was tested.