Fig. S2.

HCV RNA levels, genetic diversity, and number of viral strains in serum and multiple liver areas of patients with HCC and controls with non-HCC cirrhosis. (A) HCV RNA levels in HCC patients divided according to the drop in intrahepatic HCV RNA within the tumor in pattern 1 (<2 logs; patients 1–5) and pattern 2 (>2 logs; patients 6–8). Patient numbers are the same as in Fig. 1E. (B) Genetic diversity (distance among variants), as measured by mean Hamming distance within the HVR1 region, in serum and liver of HCC pattern 1 and 2 patients and controls. (C) Number of viral variants in serum and liver of HCC pattern 1 and 2 patients and controls. The values indicate the number of variants per 27 amino acids within the HVR1. Data represent the mean ± SEM of the results obtained from all patients within each group.