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Single-molecule force measurements on VWF monomers. (A) Schematic representation of the pulling configuration. A ybbR-tag at the N terminus and a Twin-Strep-tag at the C terminus enabled specific pulling via a Strep-Tactin functionalized cantilever. (B) Denoised force–extension trace showing a single A2 unfolding peak and lacking the high-force peak characteristic for the opening of firmly closed dimers. (C) Unimodal distribution of the position of A2 unfolding.
