Table S1.

Every dihedral angle which is biased in the simulations of chignolin, along with the reference angles (in radians) used to define the target distribution

Dihedral angle	Reference value, rad
${\psi }_1$	2.41
${\varphi }_2$	−2.52
${\psi }_2$	1.98
${\varphi }_3$	−1.58
${\psi }_3$	1.98
${\psi }_4$	−0.26
${\varphi }_5$	−0.89
${\psi }_5$	−1.15
${\varphi }_6$	−1.58
${\psi }_6$	−0.36
${\varphi }_7$	1.44
${\psi }_7$	0.078
${\varphi }_8$	−1.18
${\psi }_8$	1.86
${\varphi }_9$	−1.31
${\psi }_9$	2.35
${\varphi }_{10}$	−2.65