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. 2016 Jan 14;113(5):1273–1278. doi: 10.1073/pnas.1500992113

Fig. 1.

Fig. 1.

UPAT is required for the tumorigenicity of colon cancer cells. (A) CCSC#P, CCSC#11, or CCSC#22 cells were injected s.c. into nude mice and assessed for tumor growth. Results are expressed as the mean ± SEM (n = 6). *P < 0.05. (B) CCSC#P cells infected with a lentivirus expressing an shUPAT were injected into nude mice. Results are expressed as the mean ± SEM (n = 6). *P < 0.05. (C) CCSC#11 cells infected with a lentivirus expressing UPAT were injected into nude mice. Results are expressed as the mean ± SEM (n = 6). *P < 0.05. (D) qRT-PCR analysis of SCD1 and SPRY4 expression in HCT116 cells transfected with siRNA targeting UPAT. Results are expressed as the mean ± SEM (n = 3). (E) Viability of HCT116 cells transfected with SCD1 (Left) or SPRY4 (Right) and/or siRNA targeting UPAT was assessed by Cell Titer-Glo assays. Results are expressed as the mean ± SEM (n = 3). *P < 0.05.