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LRP1 gene deletion does not compromise cell viability. BMDMs were isolated from Cre-ERT-positive-LRP1flox/flox mice and treated with 5 µM TAM (+TAM) or vehicle (−TAM). (A) Apoptosis was measured using the Cell Death ELISA. (B) Cell viability was determined by trypan blue exclusion (mean ± SEM; n = 4; ns, not statistically significant; Mann–Whitney test).
