Fig. S6.

The relationship between gene coexpression and hub connectivity is robust to different processing methods. A and C are the same as in Fig. 3B but with different corrections applied. (A) When spatial correlations in gene coexpression values are not corrected for, gene coexpression remains increased for rich connections in the topological rich regime but does not remain increased for feeder links. (B) An alternative to the global spatial correction for gene coexpression values applied here is to correct the effect in each division separately. Exponential fits, $r_g\left(d\right)=\exp \left(-\text{η}d\right)$, are shown (where links $i\to j$ are labeled as division i), with every pair of regions shown as a point in the plot colored by their division (using the same color labels as in Fig. S1B). (C) Applying this division-based spatial correction shown in B yields similar results to that of the global spatial correction.